Researchers are interested in testing the effectiveness of a new immunosuppressive therapy to be used post-transplant to reduce graft failure in the host. Suppose researchers investigating this new therapy are concerned about the dangerous side-effects of the drug. For instance, participants that would like to enroll in the study are not allowed to already have diabetes, as the immunosuppressive agent has been found to drastically increase fasting glucose levels, which could be very dangerous for diabetics. This means, however, that participants that enter and are treated with the new drug may develop diabetes as time goes on. Suppose the following table addresses the incidence of diabetes in the study depending on treatment group. (α=.05) Type II Diabetes No Type II Diabetes Total Investigational Drug 45 19 64 Best standard of Care 70 123 193 Total 115 142 257 Ho? Ha? X2 value? x2 critical? Conclusion?
Researchers are interested in testing the effectiveness of a new immunosuppressive therapy to be used post-transplant to reduce graft failure in the host. Suppose researchers investigating this new therapy are concerned about the dangerous side-effects of the drug. For instance, participants that would like to enroll in the study are not allowed to already have diabetes, as the immunosuppressive agent has been found to drastically increase fasting glucose levels, which could be very dangerous for diabetics. This means, however, that participants that enter and are treated with the new drug may develop diabetes as time goes on. Suppose the following table addresses the incidence of diabetes in the study depending on treatment group. (α=.05)
|
|
Type II Diabetes |
No Type II Diabetes |
Total |
|
Investigational Drug |
45 |
19 |
64 |
|
Best standard of Care |
70 |
123 |
193 |
|
Total |
115 |
142 |
257 |
Ho?
Ha?
X2 value?
x2 critical?
Conclusion?
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