Researchers are interested in testing the effectiveness of a new immunosuppressive therapy to be used post-transplant to reduce graft failure in the host. Suppose researchers investigating this new therapy are concerned about the dangerous side-effects of the drug. For instance, participants that would like to enroll in the study are not allowed to already have diabetes, as the immunosuppressive agent has been found to drastically increase fasting glucose levels, which could be very dangerous for diabetics. This means, however, that participants that enter and are treated with the new drug may develop diabetes as time goes on. Suppose the following table addresses the incidence of diabetes in the study depending on treatment group. (α=.01) Type II Diabetes No Type II Diabetes Total Investigational Drug 45 32 77 Best standard of Care 35 50 85 Total 80 82 162 Based on this information complete the hypothesis steps for Chi-Squared below: H0: Ha: χ2 value: χ2 critical value: p-value: Conclusion: (Example answer: Reject or Fail to reject)
Researchers are interested in testing the effectiveness of a new immunosuppressive therapy to be used post-transplant to reduce graft failure in the host. Suppose researchers investigating this new therapy are concerned about the dangerous side-effects of the drug. For instance, participants that would like to enroll in the study are not allowed to already have diabetes, as the immunosuppressive agent has been found to drastically increase fasting glucose levels, which could be very dangerous for diabetics. This means, however, that participants that enter and are treated with the new drug may develop diabetes as time goes on. Suppose the following table addresses the incidence of diabetes in the study depending on treatment group. (α=.01)
|
|
Type II Diabetes |
No Type II Diabetes |
Total |
|
Investigational Drug |
45 |
32 |
77 |
|
Best standard of Care |
35 |
50 |
85 |
|
Total |
80 |
82 |
162 |
Based on this information complete the hypothesis steps for Chi-Squared below:
H0:
Ha:
χ2 value:
χ2 critical value:
p-value:
Conclusion: (Example answer: Reject or Fail to reject)
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