receptor protein encoded by the recessive m allele sequence cannot bind its hormone partner, and as a result the fur pigment eumelanin is not effectively produced. Briefly explain how one amino acid change might impact the function of the receptor protein. Task # 4 Genotypes and Phenotypes: The Mc1r gene is located on chromosome #16 in mice. Mice are diploid so every somatic cell has two copies of the Mc1r gene. Since there are two Mc1r alleles there are three possible genotypes: MM, Mm and mm. M=dark pigment m=less pigment Parental generation: an inland mouse (MM) mates with a beach mouse (mm)
Task #3 Impact of allelic difference: The receptor protein encoded by the recessive m allele sequence cannot bind its hormone partner, and as a result the fur pigment eumelanin is not effectively produced. Briefly explain how one amino acid change might impact the function of the receptor protein.
Task # 4 Genotypes and
M=dark pigment m=less pigment
Parental generation: an inland mouse (MM) mates with a beach mouse (mm)
A. What is the genotype of the F1 offspring? ________
B. If this trait exhibits simple (Mendelian) dominance, circle the phenotype expected for
the F1 fur color: dark pigment / medium pigment / less pigment
Observed phenotype: F1 actually have medium pigment. Initially this looks like blending, but it is not. M and m are discrete units. This observation does not disprove Mendel’s First Law which holds true for the genotypes. Individuals with genotype Mm produce more pigment than individuals with genotype mm and less than individuals with genotype MM.
C. Write the F1 x F1 cross ________ x ________ and show the gametes and offspring in a Punnett square below.
D. What genotypic and phenotypic ratios would you expect? (include the genotype or phenotype and the ratio)
E. Individuals with which genotype would be most likely to hide...
in dark inland ground cover? ________ on the white sandy beach? ________ in regions with white sand and patches of dark grass? ________
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