Exercise 3: The last Emperor of Russia, Nicolas II, was married to Empress Alexandra, and they had five children, Olga, Tatiana, Maria, Anastasia, and Alexis. Alexis was the only one who was afflicted with hemophilia or the royal bleeding disease; all other members were normal. What could be the genotypes of the Emperor and Empress? Is it possible that each daughter could have been a carrier?

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Genetic Variation

Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.

Quantitative Genetics

Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.