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Intranasal delivery has been used for several different purposes including vaccinations. Discuss and justify with evidence-based literature two (2) reasons that contraindicate the use of this route in patients?
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- Question questions. : Answer the following A) Compare between the two major types of cells. Also, explain the different levels of interactions between living organisms in the environment. B) Explain why experiments on different kinds of animals may have relevance for understanding human biology, give also, an example of such approach.a- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866609/pdf/pnas.201800195.pdfb- (Article is no longer available) Here are the articles provided within the question - They are not needed but are available if additional information is warranted - The figures being mentioned are already provided. This is Biochemoistry, please answer each part to the best of your ability. There are a max of 3 parts due to guidelines and please answer each part with clear and efficient work with answers. Thank youThe journal article "On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient [See #1 for reference]" used the methods of "Mutational pathway determines whether drug gradients accelerate evolution of drug-resistant cells [See #2 for reference]". Reference used #1 : Hermsen, R., Deris, J. B., & Hwa, T. (2012). On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient. Proceedings of the National Academy of Sciences, 109(27), 10775–10780. doi:10.1073/pnas.1117716109 #2 : Greulich, P., Waclaw, B., & Allen, R. J. (2012). Mutational Pathway Determines Whether Drug Gradients Accelerate Evolution of Drug-Resistant Cells. Physical Review Letters, 109(8). doi:10.1103/physrevlett.109.0881 QUESTIONS: 1. Based on Biological and Science manner, what is your comment/feedback on how the research articles/author presented their used material and methods?
- question: Can you summarize and explain for me what you want to tell in the article below? When I read it myself, I do not understand exactly what is meant by the article. It would be nice if you could highlight the important points. You can use them in a figure or diagram to explain. thank you and hava a nice day :) Article: Photodynamic Inactivation of SARS-CoV-2 In addition to drug- and vaccine-based antiviral strategies, photodynamic therapy (PDT) stands as a unique approach to inactivate SARS-CoV-2. Using a light-based method, PDT attacks target cells via the excitation of photosensitive agents, called photosensitizers (PSs), with radiation characterized by a wavelength corresponding to its absorption spectrum to generate reactive oxygen species (ROS) in the presence of oxygen, which ultimately results in cell death. Photodynamic therapy is primarily used for the clinical treatment of various oncological disorders. It was not until the 1970s that PDT was first used clinically…Please ASAP. Thank you. The following diagram represents the results of hemoglobin samples of 5 patients (1-5) that were run on an electrophoresis gel at pH 9.2. The first 3 lanes show the control samples, for comparison. Consider Patient 4 and Patient 5. If patient 2 is female and patient 5 is a male, and they conceive a child together, what is the chance that the child will have sickle cell anemia (the disease)? Give your answer as a percentage (%)question: Summarize the following in concise and understandable language. Nanotechnology Tools to Inactivate SARS-CoV-2 in Patients The main target of SARS-CoV-2 is the respiratory tract (upper airways, lung), although other organs might also be infected (e.g., gut, kidney) and vasculature also appears to be a prime target. The expression of ACE2 probably determines uptake by different tissues. In addition to discussing immune-based approaches, because the lung is the most critically affected organ, we will center our discussion on the various options to inactivate the virus in the deep lung and to target the essential host cells for drug delivery. The virus reaches the alveoli and enters alveolar epithelial type II cells (AECII), due to the relatively high abundance of ACE2 and a permissive cellular milieu. These cells serve as a reservoir of the virus, which finally spreads throughout the lung, leading to the lung function impairment seen in severe cases. Airborne nanomaterials are…
- The following data (in picture) were reported in a 2004 Journal of the National Cancer Institute article on recent developments in the tobacco epidemiology story in regards to lung cancer morbidity associated with "involuntary smoking" (final author, Richard Doll). a. Based on Tobacco epidemiology, explain the findings in the table (picture) b. Identify 2 of Sir Austin Bradford Hill's "Criteria for Causation" that are illustrated in these data. Explain.QUESTION: A 35-year-old man is known to have been HIV-positive for the past 10 years. Physical examination now shows multiple reddish purple, nodular skin lesions with the microscopic appearance shown in the figure. These lesions have been slowly increasing for the past year. Which of the following risk factors is most likely to play a role in the development of these skin lesions? A Antiretroviral therapy B Epstein-Barr virus infection C Hyperlipidemia D Mycobacterium avium complex infection E Sexual intercourse do fast pleaseDiscuss the potential of peptide and peptide-based inhibitors of SARS-CoV-2 entry. In your answer include the potential advantages of peptide drugs as well as challenges commonly encountered in developing peptide therapeutics.
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