Question: The beow are basics of transcription steps: Nucleosome remodeling to encourage transcriptional machinery to bind to a promoter. Pre-initiation that includes TFs binding to a core promoter sequence that recruit activators, repressors and RNA polymerase creating a pre-initiation complex. Initiation requires helicase activity to "unwind" the DNA. Promoter clearance involves the RNA polymerase unwinding and pulling DNA into the transcription complex. Consider that there is a high rate of abortion, which means promoter clearance does not occur and therefore transcription does not occur. Elongation occurs using one strand of the DNA in the 3' to 5' direction to produce a complimentary copy of the gene as a single stranded RNA molecule. Recall AT and GC associations. In RNA, the T is substituted with a U (uracil). Termination involves cleavage of the new RNA and the addition of adenines at the 3" end, which are important for translation as will be discussed in unit 4. 1. Explain the above in detail. a.) basic machinery involved in each process; b) chemistry involved in the association or enzymatic activity of basic machinery involved, c) potential aberrancies in the process that increase or decrease transcription of a particular gene. 2 Draw and label a diagram to support your discussion

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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The beow are basics of transcription steps:

Nucleosome remodeling to encourage transcriptional machinery to bind to a promoter.
Pre-initiation that includes TFs binding to a core promoter sequence that recruit activators, repressors and RNA polymerase creating a pre-initiation complex.
Initiation requires helicase activity to "unwind" the DNA.
Promoter clearance involves the RNA polymerase unwinding and pulling DNA into the transcription complex. Consider that there is a high rate of abortion, which means promoter clearance does not occur and therefore transcription does not occur.
Elongation occurs using one strand of the DNA in the 3' to 5' direction to produce a complimentary copy of the gene as a single stranded RNA molecule. Recall AT and GC associations. In RNA, the T is substituted with a U (uracil).
Termination involves cleavage of the new RNA and the addition of adenines at the 3" end, which are important for translation as will be discussed in unit 4.

Explain the above in detail.

a.) basic machinery involved in each process;

b) chemistry involved in the association or enzymatic activity of basic machinery involved,

c) potential aberrancies in the process that increase or decrease transcription of a particular gene.

Draw and label a diagram to support your discussion

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