A modification is made in the Gas (G alpha s) signaling pathway by the process of evolution. This modification results in negat feedback within the Gas pathway. Which of the following modifications would result in negative feedback that would attenuat (decrease) the resulting signal while the ligand activating the pathway is present? O A. The G-protein coupled receptor that activates Gas is endocytosed and degraded. O B. A target gene is transcribed that encodes for phosphodiesterase. O C. Adenylyl cyclase activates PKA D. Active PKA inhibits adenylyl cyclase.

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Clinical Pharmacology

Pharmacology is a discipline of medicine that studies how medications interact with the systems and processes of living organisms, focusing on drug action mechanisms as well as therapeutic and other purposes.