Answered: QUESTION NO. 1 Much of procollagen…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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QUESTION NO. 1

Much of procollagen formation occurs in the endoplasmic reticulum and Golgi apparatus which requires signal peptide. All of the following statements about targeting a protein for the ER are true except

A. signal peptide usually has a positively charged N-terminus and a stretch of hydrophobic amino acids.

B. signal peptide emerging from a free ribosome binds signal recognition particle (SRP).

C. signal peptide is usually cleaved from the protein before the protein is inserted into the ER membrane.

D. docking protein is actually an SRP receptor and serves to bind the SRP to the ER.

E. SRP and docking protein do not enter the ER lumen but are recycled

QUESTION NO. 2

All of the following statements about telomerase are correct except

A. the RNA component acts as a template for the synthesis of a segment of DNA.

B. it adds telomeric repeats to the 5'-ends of the DNA strands.

C. it provides a mechanism for replicating the ends of linear chromosomes.

D. it recognizes a G-rich single strand of DNA

E. it is a reverse transcripcase.

QUESTION NO. 3

Patients with the rare genetic disease xeroderma pigmentosum (XP) are very sensitive to light and are highly susceptible to skin cancers. The study of such patients has enhanced our knowledge of DNA repair because XP is caused by defective DNA repair nucleotide excision repair. (A variant, XP-V, is deficient in postreplication repair.) In nucleotide excision repair

A. removal of the damaged bases occurs on only one strand of the DNA.

B. only thymine dimers generated by UV light can be removed .

C. the excision nuclease is an exonuclease.

D. a single multifunctional enzyme carries out the repair process.

E. only the damaged nucleotides are removed.

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