Question 1Amyloid Precursor Protein (APP) is actually thought to be a natural neuroprotective agent induced by neuronal stress or injury.O TrueO FalseQuestion 2Which of the following is not a property of serine protease?A globular protein with high molecular weight● It is initially synthesized as a zymogenIt has uniquely activated tyrosine residue at the active siteCleaves polypeptide at a specific amino acid residueQuestion 3RTK is activated by cyclic AMP.O TrueFalse

A protein's biological function depends on its three-dimensional structure. The 3D structure is…

Answered: Question 1 Amyloid Precursor Protein…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question 10. What molecule in the cell is the first to recognize the signal peptide as it is translated by the ribosome?
Question 1: In acute lymphoblastic leukemia, the cancerous white blood cells typically lack the enzyme asparagine synthetase. Why is the administration of asparaginase an effective therapy for this type of cancer?
112
Question 12 Match the subfamilies of HSPGS withe their examples v syndecans and CD44V3 A. Secreted ECM proteoglycans v glypicans B. GPI-linked proteoglycans v perlecan and collagen XVIII C. Membrane-spanning proteoglycans v agrin
Question 19 Based on the hydropathic index plot below, where in the 3D structure of the protein would you expect to find amino acid number 185? 40 Hydrophobic 20 -20 -40 Hydrophilic 40 60 80 100 120 140 160 180 200 220 240 Residue number Alpha helix Beta sheet O Double helix O Quaternary contact O Interior of the protein O Surface of the protein Hydropathic index 20
Question 17 Which enzyme catalyzes formation of "peptide crosslinks" in peptidolgycan? O peptiodotransglycase aminoacyl transferase bacterial transpeptidase ribozymes
Question 14 If the cell membrane is severley damaged, the cell will O use special proteins to plug any holes repair the damage make cholesterol and ergosterol to repair the damage O die O rapidly reproduce
Question 16 Concerning SDS-PAGE: |A The gel is a copolymer of agarose and bis- agarose. BA magnetic field drives the migration of the proteins within the gel. C Is usually performed in presence of a molecular weight marker composed of a mixture of polynucleotides of known molecular weight. D The gel behaves like a molecular sieve. E In this type of electrophoresis the proteins migrate from the positive (+) to the neg- ative (-) electrode.
QUESTION 10 The human form of Cdk1 phosphorylates a protein called Abl, which is a kinase itself. Abl is involved in advancing the cell cycle, but it is unclear how. What problem may result if Abl is constitutively active (cannot be turned off)? QUESTION 11 What protein complex has to get loaded onto DNA during G1 but only gets activated during S phase? МСМ helicase the kinetochore The ATM DNA damage sensor O DNA polymerase QUESTION 12 are necessary for cyclin-dependent kinases to work. QUESTION 13 block cyclin-dependent kinases, turning them off. QUESTION 14 phosphorylate substrates that actually do something to move the cell cycle forward (for example, one of these phosphorylates proteins attached to the nuclear envelope and nuclear lamina to cause nuclear envelope disassembly at the start of mitosis).
QUESTION NO. 1 Much of procollagen formation occurs in the endoplasmic reticulum and Golgi apparatus which requires signal peptide. All of the following statements about targeting a protein for the ER are true except A. signal peptide usually has a positively charged N-terminus and a stretch of hydrophobic amino acids. B. signal peptide emerging from a free ribosome binds signal recognition particle (SRP). C. signal peptide is usually cleaved from the protein before the protein is inserted into the ER membrane. D. docking protein is actually an SRP receptor and serves to bind the SRP to the ER. E. SRP and docking protein do not enter the ER lumen but are recycledQUESTION NO. 2 All of the following statements about telomerase are correct except A. the RNA component acts as a template for the synthesis of a segment of DNA. B. it adds telomeric repeats to the 5'-ends of the DNA strands. C. it provides a mechanism for replicating the ends of linear…
QUESTION 6 In Proline racemase, two cysteines are positioned on opposite sides of the ring to add and remove protons This is an example of what type of enzyme mechanism? O transition state stabilization O general acid/base catalysis O nucleophilic intermediate O coenzymes / cofactors
Question 23 Short wavelength irradiation (~ 260 nm) of cells will cause which abnormality? (best answer) O hydrolysis of MRNA O cell membrane lysis O Thymine dimers in DNA O protein denaturation Question 24 Are there repair mechanisms for damage caused hy ultraviolet irradiation? If ves explain

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