Question Completion Status 30 31 32 33 34 12 13 14 16 17 1 2 10 7 11 QUESTION 17 The titration curve shown here is most likely that of Oquiv O alanine O glycine O histidine O phenylalanine leucine

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
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Question 17
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QUESTION 17
The titration curve shown here is most likely that of
OH ulv
O alanine
O glycine
O histidine
O phenylalanine
O leucine
QUESTION 18
Protein regulation often requires phosphorylation of hydroxyl groups. Which of the following amino acids in a protein is a potential site for phosphorylation?
O methionine
O cysteine
O asparagine
O tyrosine
QUESTION 19
ey are often used as buffers. In this titration curve of glycine which is the best pH region(s) I, II, IV for optimal buffering capacity of glycine? Clue: there is a
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Transcribed Image Text:Question Completion Status 30 31 32 33 34 1 2 7 12 13 14 16 17 10 11 QUESTION 17 The titration curve shown here is most likely that of OH ulv O alanine O glycine O histidine O phenylalanine O leucine QUESTION 18 Protein regulation often requires phosphorylation of hydroxyl groups. Which of the following amino acids in a protein is a potential site for phosphorylation? O methionine O cysteine O asparagine O tyrosine QUESTION 19 ey are often used as buffers. In this titration curve of glycine which is the best pH region(s) I, II, IV for optimal buffering capacity of glycine? Clue: there is a Click Save All Answers to save all answers. Save All Answers 77 6el Sayped S Spt MyCur
Expert Solution
Step 1 Introduction

A titration of amino acids is a process in which base added gradually to neutralize the acids, the functional groups of amino acids are neutralized from low to high pKa values. At low pH, net charge on all amino acids will be positive. At high pH, charge will be negative. The pH value at which no net charge on the amino acids is called as pI (isoelectric point). To find the pI value of any amino acids, we must find out the pH range where the isoelectric structure predominates. Average of the pKa values gives the pI of that amino acids.

Titration curve is graphical representation of the pH values of amino acids when sequential addition of base is performed. It s basically graph of base concentration Vs pH of solution. Generally titration curve is same for all amino acids. As we know alpha carbon of amino acids contains carboxyl, amine, side chain and H atom. Amino Acids are weak Polyprotic Acids. It is present as zwitterions at neutral pH and can be titrated with both acid/base like an amphoteric molecules. The titration curve contains equivalence point - it is basically the pH at which amino acids shows maximum buffering capacity and graph is most steep at this point. 

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