-e te C) 1st 2nd U Phe Leu (10) U 3rd U с (7) ncm5Um A (10) Leu (1)a (3) U lle (13) A Met (2) 4 (4+5) G Val (14) с CAGUCAUCAGUO с Α G с (2)b ncm³U A (2)a G

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question 1: tRNA and amino acyl tRNA synthetases

Part g: What chemical and structural characters are shared by the amino acids Ile, Val and Met?

Part h: What enzyme attaches Ile to tRNA?

Part i: Compare the frequency of the correct Ile entering the active site and the frequency of an incorrect amino acid entering the active site of this enzyme. Be specific with numbers.

Part j: Compare the frequency of the correct tRNA(Ile) entering the active site and the frequency of an incorrect tRNA entering the active site of this enzyme. Be specific with numbers.

Part k: Apply the Entropy change formula and multiply by T = 303 K (30 C) to determine the energetic cost of accurately attaching Ile to its cognate tRNA(Ile).

Part l: Is there enough energy in the chemical transformation of ATP → AMP + 2Pi to pay this information cost?

-e
te
C)
1st
2nd
U
Phe
Leu
(10)
U
3rd
U
с
(7) ncm5Um A
(10)
Leu
(1)a
(3) U
lle
(13)
A
Met
(2) 4
(4+5) G
Val
(14)
с
CAGUCAUCAGUO
с
Α
G
с
(2)b ncm³U
A
(2)a
G
Transcribed Image Text:-e te C) 1st 2nd U Phe Leu (10) U 3rd U с (7) ncm5Um A (10) Leu (1)a (3) U lle (13) A Met (2) 4 (4+5) G Val (14) с CAGUCAUCAGUO с Α G с (2)b ncm³U A (2)a G
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