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Question: Estimate the pl of the tripeptide ? Step 1: Determine what can be protonated/deprotonated Step 2: Estimate where the net charge of the protein would be = 0 Step 3: Use the pka's that bracket the neutral form. +H₂N H H H соон сно CH₂ coo- CH3 CH₂ COO H3N pka= 9.82 pka= 3.86 O O=C H H H H CH3 CH3 COO pka= 2.19

Question: Estimate the pl of the tripeptide ? Step 1: Determine what can be protonated/deprotonated Step 2: Estimate where the net charge of the protein would be = 0 Step 3: Use the pka's that bracket the neutral form. +H₂N H H H соон сно CH₂ coo- CH3 CH₂ COO H3N pka= 9.82 pka= 3.86 O O=C H H H H CH3 CH3 COO pka= 2.19

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question: Estimate the pl of the tripeptide ? Step 1: Determine what can be protonated/deprotonated Abundance Step 2: Estimate where the net charge of the protein would be = 0 Step 3: Use the pka's that bracket the neutral form. +H₂N COOH تیار کیا ہے CH₂ H CC H +1 H₂N H COOH CH3 CH3 0 1 2 cook CH₂ coof H pkg= 2.19 O H H₂N No charge H H соон CH3 CH3 3 4 pka= 3.86 Coo COO™ CH₂ H H H coof CH3 CH3 pka= 4.25 COO - 2 5 6 6 Coo J. CH₂ 7 pH O H H 8 H coo- CH3 CH3 COO" 9 + Н. H3N pka= 9.82 10 pka= 9.82 pka= 3.86 CH₂ H₂N 11 H H H coo CH₂ p - 3 O=C H H H 12 H pka= 4.25 O CH3 1 CH3 coo- CH3 CH3 COO 13 COO pka= 2.19 coo 14
Transcribed Image Text:Question: Estimate the pl of the tripeptide ? Step 1: Determine what can be protonated/deprotonated Abundance Step 2: Estimate where the net charge of the protein would be = 0 Step 3: Use the pka's that bracket the neutral form. +H₂N COOH تیار کیا ہے CH₂ H CC H +1 H₂N H COOH CH3 CH3 0 1 2 cook CH₂ coof H pkg= 2.19 O H H₂N No charge H H соон CH3 CH3 3 4 pka= 3.86 Coo COO™ CH₂ H H H coof CH3 CH3 pka= 4.25 COO - 2 5 6 6 Coo J. CH₂ 7 pH O H H 8 H coo- CH3 CH3 COO" 9 + Н. H3N pka= 9.82 10 pka= 9.82 pka= 3.86 CH₂ H₂N 11 H H H coo CH₂ p - 3 O=C H H H 12 H pka= 4.25 O CH3 1 CH3 coo- CH3 CH3 COO 13 COO pka= 2.19 coo 14
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