Question 4a-d: H9 IMR90 AT ال ... DMRS Gene Chr10 a. Name one method that could have been used to determine where the DMR are in this figure. b. How is expression of genes in the IMR90 strain (pictured in green) effected at the differentially methylated regions pictured in the figure? C. Do you suspect that methylation is higher or lower in the IMR90 strain at the DMR positions labeled in the figure? Why do you think that? d. What do you think the H9 shown on the figure is? Make at least two observations about this panel in the context of the rest of the figure.

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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Question 4a-d:
H9
IMR90
DMRS
Gene
Chr10
а.
Name one method that could have been used to determine where the DMR are in this figure.
b. How is expression of genes in the IMR90 strain (pictured in green) effected at the differentially
methylated regions pictured in the figure?
Do you suspect that methylation is higher or lower in the IMR90 strain at the DMR positions
labeled in the figure? Why do you think that?
С.
d. What do you think the H9 shown on the figure is? Make at least two observations about this
panel in the context of the rest of the figure.
Transcribed Image Text:Question 4a-d: H9 IMR90 DMRS Gene Chr10 а. Name one method that could have been used to determine where the DMR are in this figure. b. How is expression of genes in the IMR90 strain (pictured in green) effected at the differentially methylated regions pictured in the figure? Do you suspect that methylation is higher or lower in the IMR90 strain at the DMR positions labeled in the figure? Why do you think that? С. d. What do you think the H9 shown on the figure is? Make at least two observations about this panel in the context of the rest of the figure.
Question 2a-c:
After 8 rounds of backcrossing the following whole genome sequencing figure shows the data that was
found. The y-axis is graphing number of reads that are similar to the strain of the original parent to
which the F1 and further progeny were not crossed with.
PITX2
ABO
ACTN2
2
4 5 6 7 8 9
10
11
12
13 14 15 16 17 18 19202122
Chromosome
a.
ABO was the 'gene of interest' that the investigators were aiming to migrate to a new genetic
background. How could the authors possibly have ensured that the genetic information from
that loci was carried through each subsequent generation?
b. Which two other chromosomes have a loci that could potentially represent a selfish-genetic
element?
In the Ben-David et al paper that we read for class, instead of having a single stack of reads from
c.
the sequencing reaction, there was a cluster of reads that were shown on the graph. What is
one reason that you think this graph looks different than that?
(anen-dyoBo-
Transcribed Image Text:Question 2a-c: After 8 rounds of backcrossing the following whole genome sequencing figure shows the data that was found. The y-axis is graphing number of reads that are similar to the strain of the original parent to which the F1 and further progeny were not crossed with. PITX2 ABO ACTN2 2 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19202122 Chromosome a. ABO was the 'gene of interest' that the investigators were aiming to migrate to a new genetic background. How could the authors possibly have ensured that the genetic information from that loci was carried through each subsequent generation? b. Which two other chromosomes have a loci that could potentially represent a selfish-genetic element? In the Ben-David et al paper that we read for class, instead of having a single stack of reads from c. the sequencing reaction, there was a cluster of reads that were shown on the graph. What is one reason that you think this graph looks different than that? (anen-dyoBo-
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