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Question 18) Very early onset PSEN2 mutations have a more severe impact on the Aß 42/40 ratios than mutations that cause onset at a later age? Select one: O True O False

Question 18) Very early onset PSEN2 mutations have a more severe impact on the Aß 42/40 ratios than mutations that cause onset at a later age? Select one: O True O False

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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To further understand PSEN2 mutations the age of onset of Alzheimer's Disease and AB 42/40 ration is investigated for different mutations in PSEN2. Table 3 - Age at onset of FAD and measured Aß 42/40 ratios for each patient. PSEN2 Mutation Age at onset (Years) AB 42/40 ratio PSEN2 WT Select one: True False N/A 1 1229F M223L F237P M233V F237L N410Y 33 7.3+ 0.7 46 35 3.81 32 4.5 0.2 0.4 14.7 52 31 2.2 ± 1.2 1.8 20.76 + Question 18) Very early onset PSEN2 mutations have a more severe impact on the AB 42/40 ratios than mutations that cause onset at a later age?
Transcribed Image Text:To further understand PSEN2 mutations the age of onset of Alzheimer's Disease and AB 42/40 ration is investigated for different mutations in PSEN2. Table 3 - Age at onset of FAD and measured Aß 42/40 ratios for each patient. PSEN2 Mutation Age at onset (Years) AB 42/40 ratio PSEN2 WT Select one: True False N/A 1 1229F M223L F237P M233V F237L N410Y 33 7.3+ 0.7 46 35 3.81 32 4.5 0.2 0.4 14.7 52 31 2.2 ± 1.2 1.8 20.76 + Question 18) Very early onset PSEN2 mutations have a more severe impact on the AB 42/40 ratios than mutations that cause onset at a later age?
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