Proteins at work at the replication fork - Topoisomerase Replication fork movement Helicase - Next Okazaki fragment ill start here. - RNA primer Primase - RNA primer Okazaki "fragment - Single-strand- binding proteins B clamp- DNA DNA Leading strand polymerase III dimer polymerase I Lagging strand - Ligase FIGURE 7-20 The replisome and accessory proteins carry out a number of steps at the repication fork. Topoisomerase and helicase unwind and open the double helix in preparation for DNA replication. When the double helix has been unwound, single-strand-binding proteins prevent the double helix from re-forming. The ilustration is a representation of the so-called trombone model (named for its resemblance to a trombone owing to the looping of the lagging strand) showing how the two catalytic cores of the replisome are envisioned to interact to coordinate the numerous events of leading- and lagging-strand replication. LaunchPad ANIMATED ART: Loading- and lagging-strand synthesis

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Referring to Figure 7-20, answer the following questions:
a. What is the DNA polymerase I enzyme doing?
b. What other proteins are required for the DNA
polymerase III on the left to continue synthesizing
DNA?
c. What other proteins are required for the DNA
polymerase III on the right to continue synthesizing
DNA?

Proteins at work at the replication fork
- Topoisomerase
Replication
fork
movement
Helicase
- Next Okazaki fragment ill start here.
- RNA primer
Primase
- RNA primer
Okazaki
"fragment
- Single-strand-
binding proteins
B clamp-
DNA
DNA
Leading
strand
polymerase
III dimer
polymerase I
Lagging
strand
- Ligase
FIGURE 7-20 The replisome and accessory proteins carry out a number of steps at the
repication fork. Topoisomerase and helicase unwind and open the double helix in preparation
for DNA replication. When the double helix has been unwound, single-strand-binding proteins
prevent the double helix from re-forming. The ilustration is a representation of the so-called
trombone model (named for its resemblance to a trombone owing to the looping of the
lagging strand) showing how the two catalytic cores of the replisome are envisioned to interact
to coordinate the numerous events of leading- and lagging-strand replication.
LaunchPad ANIMATED ART: Loading- and lagging-strand synthesis
Transcribed Image Text:Proteins at work at the replication fork - Topoisomerase Replication fork movement Helicase - Next Okazaki fragment ill start here. - RNA primer Primase - RNA primer Okazaki "fragment - Single-strand- binding proteins B clamp- DNA DNA Leading strand polymerase III dimer polymerase I Lagging strand - Ligase FIGURE 7-20 The replisome and accessory proteins carry out a number of steps at the repication fork. Topoisomerase and helicase unwind and open the double helix in preparation for DNA replication. When the double helix has been unwound, single-strand-binding proteins prevent the double helix from re-forming. The ilustration is a representation of the so-called trombone model (named for its resemblance to a trombone owing to the looping of the lagging strand) showing how the two catalytic cores of the replisome are envisioned to interact to coordinate the numerous events of leading- and lagging-strand replication. LaunchPad ANIMATED ART: Loading- and lagging-strand synthesis
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