position 480 to arginine (G480R) in the FGFR protein. Normally, FGFR is active when FGF binds to it inhibits excessive bone growth, but the mutant FGFR is constantly active even when FGF is not bour • How can you create a mouse model for achondroplasia? Select all that apply. O Pronuclear injection of a mutant copy (G48OR) of the gene to a mouse zygote a CRISPR that knocks in a mutant copy (G48OR) of the gene to a mouse genome OCRISPR that knocks out the wild-type gene in a mouse genome O RNAI that knocks down the wild-type gene expression in a mouse genome O FGFR gene inactivated by a marker gene is introduced to embryonic stem cells
position 480 to arginine (G480R) in the FGFR protein. Normally, FGFR is active when FGF binds to it inhibits excessive bone growth, but the mutant FGFR is constantly active even when FGF is not bour • How can you create a mouse model for achondroplasia? Select all that apply. O Pronuclear injection of a mutant copy (G48OR) of the gene to a mouse zygote a CRISPR that knocks in a mutant copy (G48OR) of the gene to a mouse genome OCRISPR that knocks out the wild-type gene in a mouse genome O RNAI that knocks down the wild-type gene expression in a mouse genome O FGFR gene inactivated by a marker gene is introduced to embryonic stem cells
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
Related questions
Concept explainers
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
Topic Video
Question
Transcribed Image Text:Mutation in the fibroblast growth factor receptor (FGFR) gene results in achondroplasia (dwarfism), which is a
dominant condition caused by a single base substitution (GGG>AGG) that changes the amino acid glycine at
position 480 to arginine (G480R) in the FGFR protein. Normally, FGFR is active when FGF binds to it and
inhibits excessive bone growth, but the mutant FGFR is constantly active even when FGF is not bound to it.
o How can you create a mouse model for achondroplasia?
Select all that apply.
OPronuclear injection of a mutant copy (G48OR) of the gene to a mouse zygote
V CRISPR that knocks in a mutant copy (G480R) of the gene to a mouse genome
O CRISPR that knocks out the wild-type gene in a mouse genome
O RNAI that knocks down the wild-type gene expression in a mouse genome
O FGFR gene inactivated by a marker gene is introduced to embryonic stem cells
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education