Peptide 117: Met- Pro- Glu- Lys- His- Leu- Arg- Cys- Ile- Trp- Gln- Phe- Gly- Asn- Ala-NH2 Answer the following questions. Show all your calculations and analyses of the problems: a.) Calculate the pI of peptide 117 b.) What is the predominant form of peptide 117 at pH 8 c.) Calculate the molecular mass of peptide 117.
Q1. After years of isolation work, Peptide 117, a performance enhancing hormone, has been isolated from the pituitary glands from 10000 pregnant mice. When injected into the cranial cavity of male mice, Peptide 117 enhances their learning and reproductive performance. Peptide 117 has been cloned and the deduced amino acid sequence of 117 is given below (note that the carboxy terminal is amidated)
Peptide 117: Met- Pro- Glu- Lys- His- Leu- Arg- Cys- Ile- Trp- Gln- Phe- Gly- Asn- Ala-NH2
Answer the following questions. Show all your calculations and analyses of the problems:
a.) Calculate the pI of peptide 117
b.) What is the predominant form of peptide 117 at pH 8
c.) Calculate the molecular mass of peptide 117.
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