Peak Solution Preparation Area 0.045 g of paracetamol is weighed in a 50 mL volumetric flask and made up to the mark with methanol 0.055 g of paracetamol is weighed in a 50 mL volumetric flask and made up to the mark with methanol. 0.095 g of paracetamol is weighed in a 100 mL volumetric flask and made up to the mark with methanol. 32 mg of paracetamol is weighed in a 250 mL volumetric flask and made up to the mark with methanol. A 8957 9845 10450 D 4500

Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Chemistry

The below table shows how the paracetamol standard solutions were prepared for the

method validation and respective peak area obtained in HPLC. The best linear fit of the

calibration curve is y = 5.9999 x + 3821.1 with R2 = 0.9416. Explain why the calibration is

unacceptable and suggest how it can be improved.

Peak
Solution
Preparation
Area
0.045 g of paracetamol is weighed in a 50 mL volumetric flask
and made up to the mark with methanol
0.055 g of paracetamol is weighed in a 50 mL volumetric flask
and made up to the mark with methanol.
0.095 g of paracetamol is weighed in a 100 mL volumetric flask
and made up to the mark with methanol.
32 mg of paracetamol is weighed in a 250 mL volumetric flask
and made up to the mark with methanol.
A
8957
B
9845
C
10450
D
4500
Transcribed Image Text:Peak Solution Preparation Area 0.045 g of paracetamol is weighed in a 50 mL volumetric flask and made up to the mark with methanol 0.055 g of paracetamol is weighed in a 50 mL volumetric flask and made up to the mark with methanol. 0.095 g of paracetamol is weighed in a 100 mL volumetric flask and made up to the mark with methanol. 32 mg of paracetamol is weighed in a 250 mL volumetric flask and made up to the mark with methanol. A 8957 B 9845 C 10450 D 4500
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