OH base + H20 heat H3C H. The aldol reaction is a carbonyl condensation reaction between two carbonyl partners and involves a combination of nucleophilic addition and a-substitution steps. One partner is converted into an enolate ion nucleophile and adds to the electrophilic carbonyl group of the second partner. In the classic aldol reaction, the carbonyl partners are aldehydes or ketones, although aldehydes are more reactive. The product is a B-hydroxy carbonyl compound. In the mixed aldol reaction, the best results are obtained when one of the partners does not have an a-hydrogen. It cannot form an enolate anion and can therefore not undergo self-reaction. The enolizable aldehyde is added slowly to a basic solution of the first aldehyde so that the mixed product is preferentially formed. Under reaction conditions slightly more vigorous than those employed for the aldol reaction, the B-hydroxyl group is eliminated in an ElcB dehydration to give an a,ß-unsaturated carbonyl compound. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions OH OH Hjö: H. H. Previous Next Email Instructor Save and Exit

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ssignment/takeCovalentActivity.do?locator=assignment-take
e by the Aldol Condensation
(References)
OH
base
+ H,0
heat
H.
H3C
H.
The aldol reaction is a carbonyl condensation reaction between two carbonyl partners and involves a combination of nucleophilic addition and a-substitution steps. One partner is converted into
an enolate ion nucleophile and adds to the electrophilic carbonyl group of the second partner. In the classic aldol reaction, the carbonyl partners are aldehydes or ketones, although aldehydes are
more reactive. The product is a B-hydroxy carbonyl compound.
In the mixed aldol reaction, the best results are obtained when one of the partners does not have an a-hydrogen. It cannot form an enolate anion and can therefore not undergo self-reaction. The
enolizable aldehyde is added slowly to a basic solution of the first aldehyde so that the mixed product is preferentially formed.
Under reaction conditions slightly more vigorous than
compound.
employed for the aldol reaction, the B-hydroxyl group is eliminated in an ElcB dehydration to give an a,ß-unsaturated carbonyl
Draw curved arrows to show the movement of electrons in this step of the mechanism.
Arrow-pushing Instructions
OH
OH
H2ö:
H.
H.
H.
Previous
Next
Email Instructor
Save and Exit
Cengage Learning | Cengage Technical Support
Transcribed Image Text:resource from Cengage Learning - Google Chrome ssignment/takeCovalentActivity.do?locator=assignment-take e by the Aldol Condensation (References) OH base + H,0 heat H. H3C H. The aldol reaction is a carbonyl condensation reaction between two carbonyl partners and involves a combination of nucleophilic addition and a-substitution steps. One partner is converted into an enolate ion nucleophile and adds to the electrophilic carbonyl group of the second partner. In the classic aldol reaction, the carbonyl partners are aldehydes or ketones, although aldehydes are more reactive. The product is a B-hydroxy carbonyl compound. In the mixed aldol reaction, the best results are obtained when one of the partners does not have an a-hydrogen. It cannot form an enolate anion and can therefore not undergo self-reaction. The enolizable aldehyde is added slowly to a basic solution of the first aldehyde so that the mixed product is preferentially formed. Under reaction conditions slightly more vigorous than compound. employed for the aldol reaction, the B-hydroxyl group is eliminated in an ElcB dehydration to give an a,ß-unsaturated carbonyl Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions OH OH H2ö: H. H. H. Previous Next Email Instructor Save and Exit Cengage Learning | Cengage Technical Support
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