Consider the mechanism for the aldol condensation shown below. Which of the following statements best describe the species that are found in the arrow-pushing mechanism? cat. H2SO4 H20 А. The nucleophile is an enolate, the conjugate base is an enolate, and the leaving group is hydroxide. В. The nucleophile is an enol, the conjugate base is an enol, and the leaving group is water. The nucleophile is an enolate, the conjugate base is an enol, and the leaving group is hydroxide. D. The nucleophile is an enol, the conjugate base is an enol, and the leaving group is hydroxide.

Q: Identify reagents that can be used for the following synthesis: ? Но C CH3OH 1) CH3MgBr; 2) H20 C…

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Q: Which of the following molecules is not able to undergo an aldol self-condensation? A H3C CH3 H B…

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Q: O: LIOTIS. Me3Si-Cl CH3 CH3-Li H3C Br pyridine Create OscerSketch Answer 7 Draw the aldol product.…

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A: An aldol condensation reaction is a combination of two steps: 1. Aldol reaction where an enolizable…

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Q: 4. Give the crossed aldol product for the following reaction. NaOH (aq) + H. 25 °C

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Q: Which one of the following starting compounds is not suitable to prepare the Aldol products below? *

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Q: ОН О OH ОН О H. B For the "crossed" aldol reaction that lead to product C, did the kind of base used…

A: The structure of product C is represented as follows:

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Q: Br OH H. internal aldol condensation

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Q: Select the bond that was formed during aldol condensation to yield the following compound. В ОН C O…

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Q: 28. Identify the reagents that best complete the following reaction and show the complete mechanism

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Q: 4. Which one of the following reagents will present a mechanism by free radicals when reacted with…

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Q: 8. For the Simple Aldol and Simple Claisen Condensations; draw the full reaction mechanisms and the…

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Q: which of the following is not expected to result in an efficient crossed aldol condensation reaction

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A: Reaction 1 : Aldol condensation. Reaction 2 : Michael addition.

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Q: A. Predict the Aldol Product For each of the following give the a,ß- unsaturated carbonyl compound…

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Q: Which of the following is NOT expected to result in an efficient crossed aldol condensation…

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Q: The Robinson annulation is a combination of two carbonyl coupling reactions, the Michael reaction…

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Q: What is the product of this Aldol addition reaction

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Q: What aldol addition product is formed from the following compound?

A: The aldol addition product is formed from the following compound is given below with mechanism :

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Q: Which of the following molecules is not able to undergo an aldol self-condensation? CH₂ A H₂C 00.0 어…

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Q: How could following crossed-aldol reaction be performed to obtain the product selectively? ОН H.…

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Q: e aldol condensation is complete once the aldol product above undergoes an elimination upon heating.…

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A: Alpha proton

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.