Consider the mechanism for the aldol condensation shown below. Which of the following statements best describe the species that are found in the arrow-pushing mechanism? cat. H2SO4 H20 А. The nucleophile is an enolate, the conjugate base is an enolate, and the leaving group is hydroxide. В. The nucleophile is an enol, the conjugate base is an enol, and the leaving group is water. The nucleophile is an enolate, the conjugate base is an enol, and the leaving group is hydroxide. D. The nucleophile is an enol, the conjugate base is an enol, and the leaving group is hydroxide.

Q: 2 Li oH H Ph 2) NaoH, CH, oH phc Chme: Adol- Tischeako reaction

A: Aldol Tischenko reaction is the reaction of aldehyde or ketone to form 1,3 hydroxyl compounds. In…

Q: Which of the following molecules is not able to undergo an aldol self-condensation? A H3C CH3 H B…

A: An aldol condensation is a condensation reaction in organic chemistry in which two carbonyl moieties…

Q: Draw the enolate anion and the carbonyl that would be needed to make this product through an aldol…

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Q: 6. What is the best choice of reagent(s) to carry out the ? transformation shown here? Ph HO. Ph A)…

A: We have given three organic reaction we have to find major product obtained from these reactions.

Q: O: LIOTIS. Me3Si-Cl CH3 CH3-Li H3C Br pyridine Create OscerSketch Answer 7 Draw the aldol product.…

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Q: What is the E2 elimination product from the following reaction? There is only one.

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Q: 11. Indicate an alkyl halide with an appropriate choice of leaving group and the nucleophile that…

A: Breaking of left hand side O-C bond gives two synthons, pentyl carbocation and propoxide ion. The…

Q: If both size of the ketone and electronics of the aldehyde affect the overall reaction rate, which…

A: An aldol condensation reaction is a combination of two steps: 1. Aldol reaction where an enolizable…

Q: What is the product of the reaction shown? 1) NABH4 2) H20 C 1,1-dimethylcyclohexane C…

A: The above two reactions are the example of the synthesis of alcohols and alludes from ketone and…

Q: A student tried to prepare the following compounds using aldol condensations. Which of these…

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Q: 4. Give the crossed aldol product for the following reaction. NaOH (aq) + H. 25 °C

A: The Cross Aldol condensation reaction is a type of organic reaction . In the Reaction two Carbonyl…

Q: Draw the major product of this elimination. Consider regiochemistry and stereochemistry. Ignore…

A: When an alcohol undergoes an elimination reaction in the presence of H3O+, an alkene will be formed.

Q: Which one of the following starting compounds is not suitable to prepare the Aldol products below? *

A: A question based on reactions of aldehydes and ketones. 5 reactants are given from which the most…

Q: Give the products of the following substitution reactions. For every reaction, show electron pairs…

A: Given : We have to make the substituted products for the given reactions.

Q: 22. Propose a synthesis of the desired product from the given starting material(s). Starting…

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Q: Consider the reaction below. What would happen to its rate if the concentration of the the alkyl…

A: The effect of concentration of reactants on the rate of given reaction is to be explained. The given…

Q: 10. Using proper arrow formalism, draw the mechanism for the following reaction. OH + NH₂ H+ h

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Q: 2) Draw the mechanism and the product(s) for the following: Aldol condensation reaction H3C CH3 H OH

A: In aldol condensation reaction two molecules of aldehyde containing at least one alpha hydrogen atom…

Q: Br OH H. internal aldol condensation

A: Internal aldol condensation occurs when there are two aldehyde or ketone groups inside a molecule…

Q: Which mechanism best portrays a nucleophile attacking a ketone in protic conditions (some source of…

A: Electronegativity difference between c and o makes ketone carbon electrophilic in nature so it…

Q: The product below can be synthesized by a Robinson annulation, which is a Michael addition followed…

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Q: Draw the structure of the major organic product of the following reaction. Predict whether the…

A: The alpha hydrogen of carbonyl compounds is acidic in nature and it is removed as a proton in…

Q: 3) а. Draw the oxocarbenium ion that is formed as an intermediate in the following reaction: но OH…

A: The oxygen of atom of ketal group gets protonated which is then follwed by ring opening to produce…

Q: NaOH/H2O + HO-

A: Aldehydes, which do not have any α hydrogen atom, undergoes cannizzaro reaction when they are…

Q: Draw the aldol product C6H12O2 from two acetones. Consider the mechanism to predict the product.

A: Aldol reaction: The alpha hydrogen of carbonyl compounds is acidic in nature and it is removed as a…

Q: that would be formed from the following series of steps. Fill in the boxes with the required…

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Q: Draw the structure of the major organic product of the following reaction. Predict whether the…

A: The given reaction is Aldol reaction. In this reaction when two moiety of aldehyde or ketone (…

Q: 3. Predict the major aldol condensation products of the following reactions. Ô H H NaOH LDA NaOH…

A: NaOH and LDA (lithium diisopropylamide) are both strong bases that can be used to deprotonate…

Q: но. НО I но, I

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Q: Select the bond that was formed during aldol condensation to yield the following compound. В ОН C O…

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Q: 28. Identify the reagents that best complete the following reaction and show the complete mechanism

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Q: Identify the bonds in the compound below could be synthesized using an aldol reaction or aldol…

A: The question is based on the concept of organic synthesis.We need to identifyThe bonds which can be…

Q: t the aldol addition product of the following reaction. HO A HO m Η NaOH, ΕΙΟΗ ΟΗ D E

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Q: Compound (a) is an intermediate in the mechanism showing the formation of acetal (f). Which…

A: The reaction mechanism of formation of acetal via intermolecular reaction results in formation of a…

Q: 14. Indicate an alkyl halide with an appropriate choice of leaving group and the nucleophile that…

A: Given that, the reaction is:

Q: which of the following is not expected to result in an efficient crossed aldol condensation reaction

A: The Crossed Aldol condensation reaction takes place between two different molecules of an aldehyde…

Q: d. Predict the aldol product when the following aldehyde is allowed to react under the following…

A: Reaction 1 : Aldol condensation. Reaction 2 : Michael addition.

Q: H3C N о Ph Recognizing the results of reactions of alpha-carbon nucleophiles is a crucial skill that…

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Q: Draw the major product of this reaction. Ignore inorganic byproducts. Incorrect, 2 attempts…

A: The objective of the question is to predict the product formed in the following reaction given.

Q: A. Predict the Aldol Product For each of the following give the a,ß- unsaturated carbonyl compound…

A: Aldol condensation is a reaction in which 2 carbonyl compounds react with each other in the presence…

Q: What aldol addition product is formed from the following compound?

A: The aldol addition product is formed from the following compound is given below with mechanism :

Q: MeO. HO Me Me NaOH then HCI MeO. HO Me + H₂O

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Q: Provide the reactant(s) that would give the following aldol condensation product. H H OV O II O III…

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Q: Use appropriate reagent/reagents and provide a mechanism for each steps for the synthesis of the…

A: Organic transformation

Q: Which of the following molecules is not able to undergo an aldol self-condensation? CH₂ A H₂C 00.0 어…

A: we have to select the molecule which cannot participate in aldol self condensation

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.