The product below can be synthesized by a Robinson annulation, which is a Michael addition followed by an aldol condensation/elimination. Draw the starting materials you would use. Also draw the structure of the intermediate after the Michael addition is completed, but before the aldol reaction has started.
The product below can be synthesized by a Robinson annulation, which is a Michael addition followed by an aldol condensation/elimination. Draw the starting materials you would use. Also draw the structure of the intermediate after the Michael addition is completed, but before the aldol reaction has started.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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![**Robinson Annulation and Michael Addition**
The text discusses the synthesis of a product using a Robinson annulation, which involves a Michael addition followed by an aldol condensation/elimination.
**Instructions for Synthesis:**
1. **Draw the Starting Materials**: Identify and sketch the necessary starting materials for the reaction.
2. **Intermediate Structure**: Illustrate the structure of the intermediate after the Michael addition is completed but before the aldol reaction initiates.
**Chemical Structure Explained:**
- The diagram features a bicyclic structure with one benzene ring fused to a six-membered ring.
- The six-membered ring is in a chair conformation.
Focus on understanding the process of Michael addition and subsequent aldol reactions, as they are pivotal in organic synthesis.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F1170dbc5-b523-486c-8914-48bfcb1bffce%2F5415ec3c-f305-4e15-97e7-2f51d631faaf%2Fq2xkoee_processed.jpeg&w=3840&q=75)
Transcribed Image Text:**Robinson Annulation and Michael Addition**
The text discusses the synthesis of a product using a Robinson annulation, which involves a Michael addition followed by an aldol condensation/elimination.
**Instructions for Synthesis:**
1. **Draw the Starting Materials**: Identify and sketch the necessary starting materials for the reaction.
2. **Intermediate Structure**: Illustrate the structure of the intermediate after the Michael addition is completed but before the aldol reaction initiates.
**Chemical Structure Explained:**
- The diagram features a bicyclic structure with one benzene ring fused to a six-membered ring.
- The six-membered ring is in a chair conformation.
Focus on understanding the process of Michael addition and subsequent aldol reactions, as they are pivotal in organic synthesis.
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