O Macmillan Learning Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly The pKa values for the peptide's side chains, terminal amino groups, and carboxyl groups are provided in the table. Amino acid Amino pKa Carboxyl pKa Side-chain pKa glutamate 9.60 2.34 histidine 9.17 1.82 4.25 6.00 tryptophan 9.39 2.38 serine 9.15 2.21 glycine 9.60 2.34 leucine 9.60 2.36 arginine 9.04 2.17 12.48 proline 10.96 1.99 Calculate the net charge of the molecule at pH 3. net charge at pH 3: Calculate the net charge of the molecule at pH 8. net charge at pH 8: Calculate the net charge of the molecule at pH 11. net charge at pH 11: Estimate the isoelectric point (pl) for this peptide. pl:
O Macmillan Learning Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly The pKa values for the peptide's side chains, terminal amino groups, and carboxyl groups are provided in the table. Amino acid Amino pKa Carboxyl pKa Side-chain pKa glutamate 9.60 2.34 histidine 9.17 1.82 4.25 6.00 tryptophan 9.39 2.38 serine 9.15 2.21 glycine 9.60 2.34 leucine 9.60 2.36 arginine 9.04 2.17 12.48 proline 10.96 1.99 Calculate the net charge of the molecule at pH 3. net charge at pH 3: Calculate the net charge of the molecule at pH 8. net charge at pH 8: Calculate the net charge of the molecule at pH 11. net charge at pH 11: Estimate the isoelectric point (pl) for this peptide. pl:
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter26: Synthesis And Degradation Of Nucleotides
Section: Chapter Questions
Problem 22P
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Transcribed Image Text:O Macmillan Learning
Glu-His-Trp-Ser-Gly-Leu-Arg-Pro-Gly
The pKa values for the peptide's side chains, terminal amino groups, and carboxyl groups are provided in the table.
Amino acid Amino pKa Carboxyl pKa Side-chain pKa
glutamate
9.60
2.34
histidine
9.17
1.82
4.25
6.00
tryptophan
9.39
2.38
serine
9.15
2.21
glycine
9.60
2.34
leucine
9.60
2.36
arginine
9.04
2.17
12.48
proline
10.96
1.99
Calculate the net charge of the molecule at pH 3.
net charge at pH 3:
Calculate the net charge of the molecule at pH 8.
net charge at pH 8:
Calculate the net charge of the molecule at pH 11.
net charge at pH 11:
Estimate the isoelectric point (pl) for this peptide.
pl:
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