The ADP-ATP antiporter in the mitochondrial inner membrane can exchange ATP for ATP, ADP for ADP and ATP for ADP and is a passive antiporter. Even though mitochondria can transport both ADP and ATP in both directions, there is a strong bias in favor of exchange of external ADP for internal ATP in actively respiring mitochondria through this antiporter. ATP4- is more negative than ADP3- and thus there is biased import of ADP into the matrix and export of ATP into the intermembrane space in respiring mitochondria.
ADP, Pi, citrate and calcimycin are added to intact human mitochondria. Are a) ADP import and b) oxygen consumption and c) malate production observed? Explain your answers.
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