Red blood cells synthesize and degrade 2,3-biphosphogylerate (2,3-BPG) as a detour from the glycolytic pathway, as shown in the figure. 2,3-BPG decreases the oxygen affinity of hemoglobin by binding in the central cavity of the deoxygenated form of hemoglobin. This encourages delivery of oxygen to tissues. A defect in one of the glycolytic enzymes may affect levels of 2,3-BPG. The plot above right shows oxygen-binding curves for normal erythrocytes and for hexokinase and pyruvate kinase-deficient erythrocytes. Identify which curve corresponds to which enzyme deficiency.
Red blood cells synthesize and degrade 2,3-biphosphogylerate (2,3-BPG) as a detour from the glycolytic pathway, as shown in the figure. 2,3-BPG decreases the oxygen affinity of hemoglobin by binding in the central cavity of the deoxygenated form of hemoglobin. This encourages delivery of oxygen to tissues. A defect in one of the glycolytic enzymes may affect levels of 2,3-BPG. The plot above right shows oxygen-binding curves for normal erythrocytes and for hexokinase and pyruvate kinase-deficient erythrocytes. Identify which curve corresponds to which enzyme deficiency.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Red blood cells synthesize and degrade 2,3-biphosphogylerate (2,3-BPG) as a detour from the glycolytic pathway, as shown in the figure.
2,3-BPG decreases the oxygen affinity of hemoglobin by binding in the central cavity of the deoxygenated form of hemoglobin. This encourages delivery of oxygen to tissues. A defect in one of the glycolytic enzymes may affect levels of 2,3-BPG. The plot above right shows oxygen-binding curves for normal erythrocytes and for hexokinase and pyruvate kinase-deficient erythrocytes. Identify which curve corresponds to which enzyme deficiency.
Transcribed Image Text:20. Red blood cells synthesize and degrade 2,3-bisphosphoglyc-
erate (2,3-BPG) as a detour from the glycolytic pathway, as shown
in the figure.
Glyceraldehyde-3-P
GAPDH
1,3-Bisphosphoglycerate
1|PGK
3-Phosphoglycerate
2,3-Bisphosphoglycerate
2,3-BPG decreases the oxygen affinity of hemoglobin by binding in
the central cavity of the deoxygenated form of hemoglobin. This
encourages delivery of oxygen to tissues. A defect in one of the gly-
colytic enzymes may affect levels of 2,3-BPG. The plot above right
shows oxygen-binding curves for normal erythrocytes and for hexo-
kinase- and pyruvate kinase-deficient erythrocytes. Identify which
curve corresponds to which enzyme deficiency,
Transcribed Image Text:Oxygen saturation (%)
100
90
80
70
60
- Normal
50
40
30
20
10
0
0 10 20 30 40 50 60
po₂ (torr)
erythrocytes
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