Microsatellites are currently exploited as markers for paternity testing. A sample paternity test is shown in the following table in which ten microsatellite markers were used to test samples from a mother, her child, and an alleged father. The name of the microsatellite locus is given in the left-hand column, and the genotype of each individual is recorded as the number of repeats he or she carries at that locus. For example, at locus D9S302, the mother carries 30 repeats on one of her chromosomes and 31 on the other. In cases where an individual carries the same number of repeats on both chromosomes, only a single number is recorded. (Some of the numbers are followed by a decimal point, for example, 20.2, to indicate a partial repeat in addition to the complete repeats.) Assuming that these markers are inherited in a simple Mendelian fashion, can the alleged father be excluded as the source of the sperm that produced the child? Why or why not? Explain. Microsatellite Locus- Chromosome Location Mother Child Alleged Father D9S302-9q31-q33 30 31 32 31 32 33 D22S883-22pter-22qter 17 20.2 20.2 22 22 D18S535-18q12.2-q12.3 12 13 11 14 14 13 D7SI804-7pter-7qter 27 26 26 30 30 27 D3S2387-3p24.2.3pter 23 24 20.2 25.2 25.2 24 D4S2386-4pter-qter 12 12 12 16 D5S1719-5pter-5qter 11 10.3 10 11.3 11 10.3 CSF1PO-5q33.3.q34 11 11 10 12 12 FESFPS-15q25-15qter 11 12 10 12 13 13 TH01-11p15.5 7 7 7 8
Microsatellites are currently exploited as markers for paternity testing.
A sample paternity test is shown in the following table in which ten
microsatellite markers were used to test samples from a mother, her
child, and an alleged father. The name of the microsatellite locus is
given in the left-hand column, and the genotype of each individual is
recorded as the number of repeats he or she carries at that locus. For
example, at locus D9S302, the mother carries 30 repeats on one of her
chromosomes and 31 on the other. In cases where an individual carries
the same number of repeats on both chromosomes, only a single number
is recorded. (Some of the numbers are followed by a decimal point,
for example, 20.2, to indicate a partial repeat in addition to the complete
repeats.) Assuming that these markers are inherited in a simple
Mendelian fashion, can the alleged father be excluded as the source of
the sperm that produced the child? Why or why not? Explain.
Microsatellite Locus-
Chromosome Location
Mother Child Alleged
Father
D9S302-9q31-q33 30 31 32
31 32 33
D22S883-22pter-22qter 17 20.2 20.2
22 22
D18S535-18q12.2-q12.3 12 13 11
14 14 13
D7SI804-7pter-7qter 27 26 26
30 30 27
D3S2387-3p24.2.3pter 23 24 20.2
25.2 25.2 24
D4S2386-4pter-qter 12 12 12
16
D5S1719-5pter-5qter 11 10.3 10
11.3 11 10.3
CSF1PO-5q33.3.q34 11 11 10
12 12
FESFPS-15q25-15qter 11 12 10
12 13 13
TH01-11p15.5 7 7 7
8
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