Method DNAS sensitivity to DNase I was tested on different tissues and at different times in development. Key DNA highly sensitive to DNase I Embryonic globin gene globin genes Adult Chicken DNA U aD Results Erythroblasts first 24 hours Before hemoglobin synthesis, none of the globin genes are sensitive to DNase I digestion. a4 After globin synthesis has begun, all genes are sensitive to DNase I, but the embryonic globin gene Uis the most sensitive. Erythroblasts 5 days In the 14-day-old embryo, when only adult hemoglobin is expressed, adult genes are most sensitive and the embryonic gene is insensitive. Erythroblasts 14 days Globin genes in the brain- which does not produce globin-remain insensitive throughout development. Brain cells throughout development Conclusion: Sensitivity of DNA to digestion by DNase I is correlated with gene expression, suggesting that chromatin structure changes in the course of transcription. DNase I sensitivity is correlated with the transcription of globin genes in chick embryos.
Method DNAS sensitivity to DNase I was tested on different tissues and at different times in development. Key DNA highly sensitive to DNase I Embryonic globin gene globin genes Adult Chicken DNA U aD Results Erythroblasts first 24 hours Before hemoglobin synthesis, none of the globin genes are sensitive to DNase I digestion. a4 After globin synthesis has begun, all genes are sensitive to DNase I, but the embryonic globin gene Uis the most sensitive. Erythroblasts 5 days In the 14-day-old embryo, when only adult hemoglobin is expressed, adult genes are most sensitive and the embryonic gene is insensitive. Erythroblasts 14 days Globin genes in the brain- which does not produce globin-remain insensitive throughout development. Brain cells throughout development Conclusion: Sensitivity of DNA to digestion by DNase I is correlated with gene expression, suggesting that chromatin structure changes in the course of transcription. DNase I sensitivity is correlated with the transcription of globin genes in chick embryos.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
Based on the sensitivity of DNA to DNase I, as illustrated in Figure , which type of chicken hemoglobin (embryonic or adult) is likely to be produced in the highest quantity in the following tissues and developmental stages?
Q. Erythroblasts at day 5
Transcribed Image Text:Method DNAS sensitivity to DNase I was tested on different
tissues and at different times in development.
Key
DNA highly
sensitive
to DNase I
Embryonic
globin gene globin genes
Adult
Chicken
DNA
U aD
Results Erythroblasts
first 24 hours
Before hemoglobin synthesis,
none of the globin genes are
sensitive to DNase I digestion.
a4
After globin synthesis has
begun, all genes are sensitive
to DNase I, but the embryonic
globin gene Uis the most
sensitive.
Erythroblasts
5 days
In the 14-day-old embryo,
when only adult hemoglobin
is expressed, adult genes are
most sensitive and the
embryonic gene is insensitive.
Erythroblasts
14 days
Globin genes in the brain-
which does not produce
globin-remain insensitive
throughout development.
Brain cells
throughout
development
Conclusion: Sensitivity of DNA to digestion by DNase I is correlated with gene expression,
suggesting that chromatin structure changes in the course of transcription.
DNase I sensitivity is correlated with the transcription of globin genes
in chick embryos.
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