Mature human insulin is synthesized from a single Gene but contains two polypeptide chains (A and B) linked by disulfide bonds. Which of the following statements about the A and B chains provides the best explanation for the production of human insulin? a. They are identical and combine to form the mature insulin - A has 21 chains, B has 30 b. They are produced by proteolytic processing of a single translation product C. They are the products of alternative translation-initiation sites on a single mRNA d. They are the product of a separate A- and B-chain mRNA produced by alternative splicing - would lead to protein diversity e. They are the products of separate A- and B-chain mRNA synthesized from alternative promoters
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
44. Mature human insulin is synthesized from a single Gene but contains two polypeptide chains (A and B) linked by disulfide bonds. Which of the following statements about the A and B chains provides the best explanation for the production of human insulin?
a. They are identical and combine to form the mature insulin - A has 21 chains, B
has 30
b. They are produced by proteolytic processing of a single translation product
C. They are the products of alternative translation-initiation sites on a single mRNA
d. They are the product of a separate A- and B-chain mRNA produced by
alternative splicing - would lead to protein diversity
e. They are the products of separate A- and B-chain mRNA synthesized from
alternative promoters
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