kinetic data given below are for the reaction

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 3.6P
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(a) The kinetic data given below are for the reaction catalyzed by prostaglandin endoperoxide synthase. Focusing here on the first two columns, determine the Vmax and Km of the enzyme. • (b) Ibuprofen is an inhibitor of prostaglandin endoperoxide synthase. By inhibiting the synthesis of prostaglandins, ibuprofen reduces inflammation and pain. Using the data in the first and third columns of the table, determine the type of inhibition that ibuprofen exerts on prostaglandin endoperoxide synthase.
Rate of formation
[Arachidonic
acid]
(mm)
Rate of formation
of PGG2
(mm/min)
of PGG2 with 10
mg/mL ibuprofen
(mm/min)
0.5
23.5
16.67
1.0
32.2
25.25
1.5
36.9
30.49
2.5
41.8
37.04
3.5
44.0
38.91
Transcribed Image Text:Rate of formation [Arachidonic acid] (mm) Rate of formation of PGG2 (mm/min) of PGG2 with 10 mg/mL ibuprofen (mm/min) 0.5 23.5 16.67 1.0 32.2 25.25 1.5 36.9 30.49 2.5 41.8 37.04 3.5 44.0 38.91
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