Mrs B, aged 43 years, weight 56 kg, requires a loading dose of drug B.  The target plasma concentration is 18.9 mg/ L, volume of distribution is 0.5 L/ kg, the salt factor is 0.9 and bioavailability fraction is 1. What is the intravenous loading dose (LD) of Drug B in milligrams (mg)? units - mg LD = Cp desired x Vd                         S x F   Where Cp desired is the target plasma

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