A 129.8 pound patient was prescribed an oral antidepressant. The medication was prescribed as 50 mg PO Q8 H. This antidepressant has a 10.4 hour elimination half-life, a 0.8 L/kg volume of distribution, a 30.7% oral bioavailability, and a 1.5 hour absorption half-life. What is the average steady state drug concentration of the antidepressant in this patient? NOTE: Please provide your answer in units of ug/L. Do not include units in your answer.
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- Analgesia plan for a cat with urinary obstruction: Buprenorphine (for pain) 4.54kgx0.03mg/kg =0.1362mg÷0.3mg/ml=0.45ml Meloxicam (Anti-inflammatory): 4.54 kg x 0.3 mg/kg = 1.3662 mg ÷ 5 mg/ml = 0.27 ml * Please calculate for 4 days, since the cat will remain in the hospital for 4 days.The instructions for the azithromycin state to reconstitute the 600 mg vial with 3.6 mL until dissolved, to yield a strength of 150 mg/mL, and then to add it to 270 mL of D5W and administer over at least 60 minutes. At what rate will you set the infusion pump if you choose to administer the medication over 90 minutes? order:Please show dimensional analysis to solve
- Explain the term first-pass eject or hepatic metabolism of the drug. What effect does first-pass have on drug bioavailability and activity?Depression- Cardiovascular disease: Mr VV, a 67 year old suffered a myocardial infarction 2 weeks ago. He is showing signs of mild-moderate depression. Knowing that depression is a poor prognostic factor for survival post-MI, the cardiac team refer him to you. His current medicines are: Aspirin 75mg od Atenolol 100mg 0d Simvastatin 10mg od Enalapril 10mg od The hospital formulary states that fluoxetine 20mg should be prescribed if all factors are equal. Is this a good choice? Can you suggest an alternative if this is not the case? What are the recommendations about SSRIs in relation to cardiotoxicity?a 175 lb paitent is to undergo surgery and will be given an intervenous anesthetic. The safe dosage of anesthetic is up to 12.0 mg/kg of body weight. Determine the maximum dose ( in mg) of anesthetic that should be used.
- NDC 16571-013-01 Piroxicam Capsules USP, 20 mg Rev. 00 PHARMACIST: Dispense the enclosed Medication Guide to each patient 100 Capsules R Only PACK PHARMACEUTICALA LIC USUAL DOSAGE: See Package Insert. Store at 20-25°C (68-77°F): excursions permitted to 15-30°C (59-86°F). [See USP Controlled Room Temperature.] WARNING: AS WITH ALL MEDICATIONS, KEEP OUT OF REACH OF CHILDREN. EACH CAPSULE CONTAINS: Piroxicam USP 20 mg Dispense in a tight, light-resistant container as defined in the USP Manufactured by Nostrum Laboratories, Inc. Kansas City, MO 64120 Distributed by: PACK Pharmaceuticals, LLC Buffalo Grove, IL 60089 3 16571 01301 Lot No: Non Varnish Area Exp. Date: Use the medication label to complete these calculations. The drug label will supply the dosage strength and the unit. The healthcare provider orders 80 mg of piroxicam per day. How many capsules should be given for this dose?4) A 45-year old woman weighing 68 kg is admitted to hospital after a drug overdose. A toxic plasma concentration of 264 mg/mL is recorded on admission. After 35 hours, a plasma concentration of 8.25mg/ml is recorded. Given this information, calculate the half life for this drug.(Assume the distribution is complete and that the elimination is described by a first-order process.)unit- hoursA 10-week-old child suffered from a salt-wasting crisis. His adrenal glands were enlarged and other organs were normal size. The child is phenotypically female, karotyping showed that the child is 46XY. The biochemical profile shows as: - sodium of 109 (reference range: 134-147) - potassium of 6.1 (reference range: 3.5-5.0) - pregnenlone of 0.002 (reference range: 0.3-1.5) - renin activity of 38 (reference range: 0.5-3.5) - 17-OH pregnenolone of 0.01 (reference range: 6.8-93.5) - ACTH of 1960 (reference range: 0.5-3.5) The cholesterol esters in the adrenal glands accumulated and the concentration of ∆4-androstenedione was not detectable. Also, the enzymes in the steroid biosynthesis did not have detrimental mutations. The child was given treatment with glucocorticoid and mineralocorticoid. Question: a) Which protein is deficient in this case and explain the rationale.
- Can you Analyze the responsive behaviors of both partners and relate these to infant language and social: https://www.youtube.com/watch?v=9FeTK7ZXmVI&ab_channel=ChrisMoyerA 158lb adult male diagnosed with endocarditis has an order for gentamicin 3mg/kg/day IV in 2 divided doses, in addition to vancomycin. The Gentamicin is available in 2 mL vials containing 40mg/mL. The facility protocol is to round the gentamicin dose to the nearest 10mg, then calculate the volume of solution to the nearest tenth mL. How many mL will administer per dose?A 70-year-old female patient with Parkinson’s disease has been taking carbidopa/levodopa for five years. Twelve months ago, her physician changed the dose to 8 orally disintegrating tablets (25/100 mg) per day and her symptoms were well-managed until recently. For the last a few weeks, the patient has been experiencing tremors in the hands and slowness in movement towards the end of the dosing interval. Identify the problem and suggest a pharmacotherapy management option for this patient.A 55-year-old male patient has mild dementia and mild hepatic impairment. The patient was recently diagnosed with Parkinson’s disease. Consider carbidopa/levodopa, tolcapone, and rasagiline to initiate treatment.Explain pharmacotherapy of migraine targeting the calcitonin gene-related peptide. Please answer at your own easy words. Answer should be to the point specific. I will rate you positive if you do so. Please don't use AI for answering this question.