It's a three part question based on the chart provided asking: a) Which of these enzymes has the weakest binding of substrate? (I chose fumarase since it has lowest Km but that was wrong so I don't understand) b) Which enzyme has the fastest conversion of ES? (I would assume this means highest Kcat value, so should be catalase) c) Which enzyme is most closely catalytically perfect? (I'm assuming this means highest Kcat/Km ratio, so I was thinking Crotonase, although I don't know what classifies an enzymes as 'catalytically perfect', please explain)
It's a three part question based on the chart provided asking: a) Which of these enzymes has the weakest binding of substrate? (I chose fumarase since it has lowest Km but that was wrong so I don't understand) b) Which enzyme has the fastest conversion of ES? (I would assume this means highest Kcat value, so should be catalase) c) Which enzyme is most closely catalytically perfect? (I'm assuming this means highest Kcat/Km ratio, so I was thinking Crotonase, although I don't know what classifies an enzymes as 'catalytically perfect', please explain)
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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It's a three part question based on the chart provided asking:
a) Which of these enzymes has the weakest binding of substrate? (I chose fumarase since it has lowest Km but that was wrong so I don't understand)
b) Which enzyme has the fastest conversion of ES? (I would assume this means highest Kcat value, so should be catalase)
c) Which enzyme is most closely catalytically perfect? (I'm assuming this means highest Kcat/Km ratio, so I was thinking Crotonase, although I don't know what classifies an enzymes as 'catalytically perfect', please explain)
Transcribed Image Text:TABLE 6-8 Enzymes for Which k/K Is Close to the
cat
m
Kat
Enzyme
Substrate
(S-¹)
Acetylcholinesterase
Acetylcholine
1.4 X 10¹
Carbonic anhydrase
CO₂
1 X 10°
4 X 10¹
HCO,
Catalase
4 X 10'
H₂O₂
Crotonyl-CoA
Crotonase
5.7 X 10³
Fumarase
Fumarate
8 x 10²
Malate
9 X 10²
B-Lactamase
Benzylpenicillin
2.0 X 10³
Diffusion-Controlled Limit (10³ to 10² m¯¹s¯¹)
K
(M)
cat
m
(M-¹S-¹)
9 X 10.⁹
1.6 X 10⁹
1.2 x 10-²
8.3 X 10²
2.6 x 10-²
1.5 X 10'
1.1 X 10⁰
4 X 10'
2 X 105
2.8 X 108
5 x 10-6
1.6 X 108
2.5 X 10-$
3.6 X 10'
2 X 10-⁹
1 X 10⁰
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