In one form of thalassemia, the mutation of a single base from G to A generates a new 3' splice site that is farther upstreamfrom the normal site. The normal and mutated sequences show the sense DNA strands of a normal and thalassemic patient.5' CCTATTGGTCTATTTTCCACCCTTAGGCTGCTG 3'5' CCTATTAGTCTATTTTCCACCCTTAGGCTGCTG 3'3' end of mutated intron New start of reading frameNormal 3' end of intronWhat is the amino acid sequence of the extra segment of protein synthesized in a thalassemic patient that results from theaberrant splicing?Use the codon table and write the peptide sequence using three-letter amino acid abbreviations separated by hyphens.amino acid sequence:Pro-The-Ser-Leu-Phe-Ser-Thr-Leu-Arg-Leu-LeuIncorrect

As per the central dogma of molecular biology, genetic information is stored in the DNA. The genetic…

Answered: In one form of thalassemia, the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

For the ovalbumin gene shown, indicate the locations of the following: (a) transcription start site, (b) template strand, and (c) promoter.
Translate the RNA codons using the given genetic code 5' A-U-C-G-A-C-G-A-U-C-C-G-A-U-C-G-A-U 3'
The following DNA strand is a template strand (also called non-coding strand) of an E. coli gene. Arrow indicates the direction of transcription. The asterisk indicates t transcription initiation site GCAGTGACCGGATATAACGAAGAGGAATGCCGTACAAA 5' GCAGTGA 3' -10 Which of the following sequences accurately represents the RNA derived from this gene? C5' UCCUUAC 3' C3' UCCUUAC 5' C5' CGUCACU 3' +10 3' AGGAATG 5'
The template strand of a gene has the sequence 5'-ATGCCTAGCCTAGGACT-3'. What will the sequence of the transcript from this gene be? 5' AGUCCUAGGCUAGGCAU 3 5 ATGCCTAGCCTAGGACT 3' 5 AUGCCUAGCCUAGGACU 3' 5' MAUGCCUAGCCUAGGACUAAAAAAAAAA 3" 5' AGTCCTAGGCTAGGCAT 3" V.
In the following figure, provide RNA sequence of Gene a and Gene b in a 5'-3' direction. Provide the DNA sequence of Gene c on the non-template strand. 4. Genes a and c are transcribed from the bot strand,... RNA DNA 5' 3 Gene a GGACCTA Gene b Gene c 3' 5' ACGTCAG RNA RNA UUAGAUC ...and b is transcribed from the top strand.
A lilP mutant called lilPXS is isolated that produces a truncated polypeptide of only 6 AA in length. Describe a single basepair DNA change that would lead to this truncated version of the protein. Multiple options are possible（100 words maximum）
Please fill out the following table. Circle sense or template strands. Indicate 5’, 3’, amino and carboxy ends. Use wobble whenever possible
Please in detail, what the picture attached represents
For this double stranded DNA: 3’-AGGTCCAGTCTTCGGCGGATGATCGGGCCAACCCCCGTAACTGGTCACCGGAATGCC-5’ 5’-TCCAGGTCAGAAGCCGCCTACTAGCCCGGTTGGGGGCATTGACCAGTGGCCTTACGG -3’ , while using the bottom strand is the template for transcription. If the START CODON is AUG and the STOP CODON IS UGA, how many amino acids are in the encoded protein and what is the primary structure?
The coding (or “sense”)strand(again noticename ANDthe directionality)of DNAthat is known to encode the C-terminal end of a long E. coliprotein has the following nucleotide sequence:5′–CCATGCAAAGTAATAGGT–3′Give the sequence of the last three amino acids of the protein (label the C-terminus).
The following is a section of the gene coding for bovine rhodopsin along with several restriction endonucleases, their recognition sequences, and their hydrolysis sites. Which endonucleases will catalyze cleavage of this section of DNA? 5-GCCGTCTACAАСССGGTCATCTAАСТАТСАТGATCААСАAGCAGTTCCGGAACT-3' Recognition Sequence Recognition Sequence Enzyme Enzyme AG | CT TGG | CCA CG I CG GG | CC CI CGG | GATC GC | GGCCGC GAGCT | C Alul Hpall Ball Mbol FnuDII NotI HealII Sad
Given Sequence: 3’-TACGGTCCGGATTCGGTAGCTAGCATC-5’ Provide: Complementary Strand: Transcript Amino Acid Sequence 2.Given Sequence: 5’-GGGCATATGCCGTTTACCGGTTTGACTAAATAACCA-3’ Provide: Complementary Strand: Transcript Amino Acid Sequence 3.Given Sequence: 3’-AAC CAA TAC GTG AGG ATA CCA AGT AAC ACT CCC-5’ Provide: Complementary Strand: Direct Transcript: Transcript for Translation: Amino Acid Sequence:

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