In 1952, an article in the British Medical Journalreported interesting differences in the behavior ofblood plasma obtained from several people who suffered from X-linked recessive hemophilia. Whenmixed together, the cell-free blood plasma from certain combinations of individuals could form clots inthe test tube. For example, the following table showswhether clots could form (+) or not (−) in variouscombinations of plasma from four people withhemophilia:1 and 1 − 2 and 3 +1 and 2 − 2 and 4 +1 and 3 + 3 and 3 −1 and 4 + 3 and 4 −2 and 2 − 4 and 4 −What do these data tell you about the inheritance ofhemophilia in these individuals? Do these data allowyou to exclude any models for the biochemical pathway governing blood clotting?

Human Anatomy & Physiology (11th Edition)
11th Edition
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Author:Elaine N. Marieb, Katja N. Hoehn
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In 1952, an article in the British Medical Journal
reported interesting differences in the behavior of
blood plasma obtained from several people who suffered from X-linked recessive hemophilia. When
mixed together, the cell-free blood plasma from certain combinations of individuals could form clots in
the test tube. For example, the following table shows
whether clots could form (+) or not (−) in various
combinations of plasma from four people with
hemophilia:
1 and 1 − 2 and 3 +
1 and 2 − 2 and 4 +
1 and 3 + 3 and 3 −
1 and 4 + 3 and 4 −
2 and 2 − 4 and 4 −
What do these data tell you about the inheritance of
hemophilia in these individuals? Do these data allow
you to exclude any models for the biochemical pathway governing blood clotting?

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