On rare occasions, people are born with a condition known as uniparental disomy. It happens when an individual inherits both copies of achromosome from one parent and no copies from the other parent. Thisoccurs when two abnormal gametes happen to complement each otherto produce a diploid zygote. For example, an abnormal sperm thatlacks chromosome 15 could fertilize an egg that contains two copies ofchromosome 15. In this situation, the individual has maternal uniparental disomy 15 because both copies of chromosome 15 were inheritedfrom the mother. Alternatively, an abnormal sperm with two copies ofchromosome 15 could fertilize an egg with no copies. This is known aspaternal uniparental disomy 15. If a female is born with paternal uniparental disomy 15, would you expect her to be phenotypically normal,have Angelman syndrome (AS), or have Prader-Willi syndrome(PWS)? Explain. Would you expect her to produce normal offspring oroffspring affected with AS or PWS?
On rare occasions, people are born with a condition known as uniparental disomy. It happens when an individual inherits both copies of a
chromosome from one parent and no copies from the other parent. This
occurs when two abnormal gametes happen to complement each other
to produce a diploid zygote. For example, an abnormal sperm that
lacks chromosome 15 could fertilize an egg that contains two copies of
chromosome 15. In this situation, the individual has maternal uniparental disomy 15 because both copies of chromosome 15 were inherited
from the mother. Alternatively, an abnormal sperm with two copies of
chromosome 15 could fertilize an egg with no copies. This is known as
paternal uniparental disomy 15. If a female is born with paternal uniparental disomy 15, would you expect her to be
have Angelman syndrome (AS), or have Prader-Willi syndrome
(PWS)? Explain. Would you expect her to produce normal offspring or
offspring affected with AS or PWS?
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