A couple planning their family are aware that through the pastthree generations on the husband’s side a substantial numberof stillbirths have occurred and several malformed babies wereborn who died early in childhood. The wife has studied geneticsand urges her husband to visit a genetic counseling clinic,where a complete karyotype-banding analysis is performed.Although the tests show that he has a normal complement of46 chromosomes, banding analysis reveals that one memberof the chromosome 1 pair (in group A) contains an inversioncovering 70 percent of its length. The homolog of chromosome1 and all other chromosomes show the normal bandingsequence. Question: What can you predict about the probability of abnormality/normality of their future children?
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
A couple planning their family are aware that through the past
three generations on the husband’s side a substantial number
of stillbirths have occurred and several malformed babies were
born who died early in childhood. The wife has studied genetics
and urges her husband to visit a genetic counseling clinic,
where a complete karyotype-banding analysis is performed.
Although the tests show that he has a normal complement of
46 chromosomes, banding analysis reveals that one member
of the chromosome 1 pair (in group A) contains an inversion
covering 70 percent of its length. The homolog of chromosome
1 and all other chromosomes show the normal banding
sequence.
Question: What can you predict about the probability of abnormality/
normality of their future children?
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