A couple planning their family are aware that through the past three generations on the husband's side a substantial number of stillbirths have occurred and several malformed babies were born who died early in childhood. The wife has studies genetics and urges her husband to visit a genetic counseling clinic, where a complete karyotype-banding analysis is performed. Although the tests show that he has a normal complement of 46 chromosomes, banding analysis reveals that one member of the chromosome 1 pair (in group A) contains an inversion covering 70 percent of its length. The homolog of chromosome 1 and all other chromosomes show the normal banding sequence. (a) How would you explain the high incidence of past stillbirths? predict about the probability of (b) What can you abnormality/normality of their future children? (c) Would you advise the woman that she will have to bring each pregnancy to term to determine whether the fetus is normal? If not, what else can you suggest?
A couple planning their family are aware that through the past three
generations on the husband's side a substantial number of stillbirths
have occurred and several malformed babies were born who died
early in childhood. The wife has studies genetics and urges her
husband to visit a genetic counseling clinic, where a complete
karyotype-banding analysis is performed. Although the tests show
that he has a normal complement of 46 chromosomes, banding
analysis reveals that one member of the chromosome 1 pair (in
group A) contains an inversion covering 70 percent of its length.
The homolog of chromosome 1 and all other chromosomes show
the normal banding sequence.
(a) How would you explain the high incidence of past stillbirths?
predict
about
the
probability
of
(b) What can you abnormality/normality of their future children?
(c) Would you advise the woman that she will have to bring each pregnancy to term to determine whether the fetus is normal? If
not, what else can you suggest?
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