why The chromatids formed byrecombination within the inversion loop of a pericentric inversionheterozygote are genetically unbalanced?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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why The chromatids formed by
recombination within the inversion loop of a pericentric inversion
heterozygote are genetically unbalanced?

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When the region between two breaks of the same chromosome rotate 180°, it results in chromosomal aberration called inversion. When the inversion occurs between the arms of the same chromosome, it is called paracentric but when inversion involves the centromere along with arms it is called pericentric. Heterozygotes for the inversion are generally phenotypic normal but their gamete’s quality and fertility can be affected causing the recombination in inverted region.

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