Duchenne muscular dystrophy (DMD) is caused bya recessive mutant allele of an X-linked gene calleddystrophin. Rarely, females have disease symptomsas severe as those in males hemizygous for therecessive allele. These females are heterozygous forX-autosome reciprocal translocations where the Xchromosome breakage occurred in the middle of thedystrophin gene, breaking it into two pieces.a. If it is equally likely for X chromosome inactivation to spread from either of the X chromosomeinactivation centers (XICs; see Fig. 12.15) in thecells of this patient, what proportion of her cellswould you expect to have normal function of thedystrophin gene?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Duchenne muscular dystrophy (DMD) is caused by
a recessive mutant allele of an X-linked gene called
dystrophin. Rarely, females have disease symptoms
as severe as those in males hemizygous for the
recessive allele. These females are heterozygous for
X-autosome reciprocal translocations where the X
chromosome breakage occurred in the middle of the
dystrophin gene, breaking it into two pieces.
a. If it is equally likely for X chromosome inactivation to spread from either of the X chromosome
inactivation centers (XICs; see Fig. 12.15) in the
cells of this patient, what proportion of her cells
would you expect to have normal function of the
dystrophin gene?

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