A woman with no phenotype is known to have a 14:21 translocation. Please answer questions 1 and 2. 1. With respect to only chromosomes 14 and 21, how many distinct chromosome combinations will happen in her eggs? What portion will be viable? 2. If she has children with a normal man (no translocations), what is the probability that they have a daughter with Down Syndrome or a son with no phenotype?
A woman with no
1. With respect to only chromosomes 14 and 21, how many distinct chromosome combinations will happen in her eggs? What portion will be viable?
2. If she has children with a normal man (no translocations), what is the probability that they have a daughter with Down Syndrome or a son with no phenotype?
Between two acrocentric chromosomes where the centromere is at one end of the chromosome—Robertsonian translocations take place, leaving a short length of genetic material beyond the centromere.
The human genome has six acrocentric chromosomes: 13, 14, 15, 21, 22, and the Y chromosome.
1. The risk of infertility or miscarriage increases in Robertsonian translocation carrier women. A child born to a person with this translocation who carries the pregnancy to term may be more susceptible to chromosomal imbalance. While asymptomatic, Robertsonian translocation carriers frequently produce imbalanced gametes, leading to monosomal or trisomy zygotes.
Monosomy 14, Trisomy 14, and Monosomy 21 are the two most fatal segregants. Monosomy 14 and 21 can be carried throughout pregnancies due to Robertsonian translocations. Both are thought to be unviable.
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