An STR on chromosome 9 is immediately adjacent to a gene involved in a dominant blood disorder (only one copy of the mutation is required for the disease). Thus, in a family with a known mutation in the disorder-causing gene, inheritance of the STR can be used to diagnose the disorder. There are four different alleles of the STR (A, B, C and D), each with different numbers of GATCTCG repeats. The A allele has 10 repeats, the B allele has 19 repeats, the Callele has 25 repeats, and the D allele has 13 repeats. Part 1. Lane 1 of the gel shown below indicates the locations of PCR products corresponding to all four STR alleles when run together in one lane. DNA was loaded into the wells at the top of the gel. Lane 1 Janavi Mehmet Prita Kamu Ravi Shreeta List the location of each allele by its letter in order from top (- side of gel) to bottom (+ side of gel). BIUA - A - I E E 3 x' x, E E 14pt Paragraph

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
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Chapter11: Genome Alterations: Mutation And Epigenetics
Section: Chapter Questions
Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...
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An STR on chromosome 9 is immediately adjacent to a gene involved in a dominant blood disorder (only one copy of the mutation is required for the disease). Thus, in a family
with a known mutation in the disorder-causing gene, inheritance of the STR can be used to diagnose the disorder. There are four different alleles of the STR (A, B, C and D), each
with different numbers of GATCTCG repeats. The A allele has 10 repeats, the Ballele has 19 repeats, the Callele has 25 repeats, and the D allele has 13 repeats.
Part 1.
Lane 1 of the gel shown below indicates the locations of PCR products corresponding to all four STR alleles when run together in one lane. DNA was loaded into the wells at the
top of the gel.
Lane 1
Janavi Mehmet
Prita
Кamu
Ravi
Shreeta
List the location of each allele by its letter in order from top (- side of gel) to bottom (+ side of gel).
BI U
A - A - I E E 3 x x, = E 14pt
Paragraph
曲、
Transcribed Image Text:ques An STR on chromosome 9 is immediately adjacent to a gene involved in a dominant blood disorder (only one copy of the mutation is required for the disease). Thus, in a family with a known mutation in the disorder-causing gene, inheritance of the STR can be used to diagnose the disorder. There are four different alleles of the STR (A, B, C and D), each with different numbers of GATCTCG repeats. The A allele has 10 repeats, the Ballele has 19 repeats, the Callele has 25 repeats, and the D allele has 13 repeats. Part 1. Lane 1 of the gel shown below indicates the locations of PCR products corresponding to all four STR alleles when run together in one lane. DNA was loaded into the wells at the top of the gel. Lane 1 Janavi Mehmet Prita Кamu Ravi Shreeta List the location of each allele by its letter in order from top (- side of gel) to bottom (+ side of gel). BI U A - A - I E E 3 x x, = E 14pt Paragraph 曲、
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