An STR on chromosome 9 is immediately adjacent to a gene involved in a dominant blood disorder (only one copy of the mutation is required for the disease). Thus, in a family with a known mutation in the disorder-causing gene, inheritance of the STR can be used to diagnose the disorder. There are four different alleles of the STR (A, B, C and D), each with different numbers of GATCTCG repeats. The A allele has 10 repeats, the B allele has 19 repeats, the Callele has 25 repeats, and the D allele has 13 repeats. Part 1. Lane 1 of the gel shown below indicates the locations of PCR products corresponding to all four STR alleles when run together in one lane. DNA was loaded into the wells at the top of the gel. Lane 1 Janavi Mehmet Prita Kamu Ravi Shreeta List the location of each allele by its letter in order from top (- side of gel) to bottom (+ side of gel). BIUA - A - I E E 3 x' x, E E 14pt Paragraph

An STR on chromosome 9 is immediately adjacent to a gene involved in a dominant blood disorder (only one copy of the mutation is required for the disease). Thus, in a family with a known mutation in the disorder-causing gene, inheritance of the STR can be used to diagnose the disorder. There are four different alleles of the STR (A, B, C and D), each with different numbers of GATCTCG repeats. The A allele has 10 repeats, the B allele has 19 repeats, the Callele has 25 repeats, and the D allele has 13 repeats. Part 1. Lane 1 of the gel shown below indicates the locations of PCR products corresponding to all four STR alleles when run together in one lane. DNA was loaded into the wells at the top of the gel. Lane 1 Janavi Mehmet Prita Kamu Ravi Shreeta List the location of each allele by its letter in order from top (- side of gel) to bottom (+ side of gel). BIUA - A - I E E 3 x' x, E E 14pt Paragraph

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...

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An STR on chromosome 5 is very closely linked to a gene involved in a dominant metabolism disorder (one one copy of the mutation causes the disease). There are four different alleles of the STR (Q, B, S, and L), each with different numbers of GATCTCG repeats. The S allele has 2 repeats, the B allele has 7 repeats, the Q allele has 10 repeats, and the L allele has 5 repeats. Part 1 Lane 1 of the gel shown below indicates the locations of PCR products corresponding to all four STR alleles when run together in one lane. DNA was loaded into the wells at the top of the gel. Move the letter of each allele to its correct position at the left of Lane 1 to indicate where each allele runs on the gel. 0000 Gabriel Andre Lane 1 O Maria Andre Maria Juliana B L Part 2 Andre and Maria are the parents in this family; all others shown on the gel are children. Daughter Juliana is born with the metabolism disorder, but daughter Camila does not have the disorder. Assuming no recombination between the STR…
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Propose an explanation for the small amount of enzyme E produced by genotype 3.
The gene controlling ABO blood type and the gene underlying nail-patella syndrome are said to show linkage. What does that mean in terms of their relative locations in the genome? What does it mean in terms of how the two traits are inherited with respect to each other?