A female patient 19 years old, whose symptoms areanemia and internal bleeding due to a massive buildupof leukemic white blood cells, is diagnosed withchronic myelogenous leukemia (CML). Karyotypeanalysis shows that the leukemic cells of this patientare heterozygous for a reciprocal translocation involving chromosomes 9 and 22. However, none of thenormal, nonleukemic cells of this patient contain thetranslocation. Which of the following statements istrue and which is false?a. The translocation results in the inactivation (loss offunction) of a tumor-suppressor gene.b. The translocation results in the inactivation (loss offunction) of an oncogene.c. There is a 50% chance that any child of this patientwill have CML.d. This patient is a somatic mosaic in terms of thekaryotype.e. DNA extracted from leukemic cells of this patient,if taken up by normal mouse tissue culture cells,could potentially transform the mouse cells intocells capable of causing tumors.f. The normal function of the affected tumor-suppressorgene or proto-oncogene at the translocation breakpoint could potentially block the function of thecyclin proteins that drive the cell cycle forward.
A female patient 19 years old, whose symptoms are
anemia and internal bleeding due to a massive buildup
of leukemic white blood cells, is diagnosed with
chronic myelogenous leukemia (CML). Karyotype
analysis shows that the leukemic cells of this patient
are heterozygous for a reciprocal translocation involving chromosomes 9 and 22. However, none of the
normal, nonleukemic cells of this patient contain the
translocation. Which of the following statements is
true and which is false?
a. The translocation results in the inactivation (loss of
function) of a tumor-suppressor gene.
b. The translocation results in the inactivation (loss of
function) of an oncogene.
c. There is a 50% chance that any child of this patient
will have CML.
d. This patient is a somatic mosaic in terms of the
karyotype.
e. DNA extracted from leukemic cells of this patient,
if taken up by normal mouse tissue culture cells,
could potentially transform the mouse cells into
cells capable of causing tumors.
f. The normal function of the affected tumor-suppressor
gene or proto-oncogene at the translocation breakpoint could potentially block the function of the
cyclin proteins that drive the cell cycle forward.
Trending now
This is a popular solution!
Step by step
Solved in 4 steps
