Oncogenes sometimes result from genetic rearrangements(e.g., translocations) that produce gene fusions. An exampleoccurs with the Philadelphia chromosome, in which a reciprocaltranslocation between chromosomes 9 and 22 leads to fusion of thefirst part of the bcr gene with the abl gene. Suggest two differentreasons why a gene fusion can create an oncogene.
Genetic Recombination
Recombination is crucial to this process because it allows genes to be reassorted into diverse combinations. Genetic recombination is the process of combining genetic components from two different origins into a single unit. In prokaryotes, genetic recombination takes place by the unilateral transfer of deoxyribonucleic acid. It includes transduction, transformation, and conjugation. The genetic exchange occurring between homologous deoxyribonucleic acid sequences (DNA) from two different sources is termed general recombination. For this to happen, an identical sequence of the two recombining molecules is required. The process of genetic exchange which occurs in eukaryotes during sexual reproduction such as meiosis is an example of this type of genetic recombination.
Microbial Genetics
Genes are the functional units of heredity. They transfer characteristic information from parents to the offspring.
Oncogenes sometimes result from genetic rearrangements
(e.g., translocations) that produce gene fusions. An example
occurs with the Philadelphia chromosome, in which a reciprocal
translocation between chromosomes 9 and 22 leads to fusion of the
first part of the bcr gene with the abl gene. Suggest two different
reasons why a gene fusion can create an oncogene.
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