A couple planning their family are aware that through the pastthree generations on the husband’s side a substantial numberof stillbirths have occurred and several malformed babies wereborn who died early in childhood. The wife has studied geneticsand urges her husband to visit a genetic counseling clinic,where a complete karyotype-banding analysis is performed.Although the tests show that he has a normal complement of46 chromosomes, banding analysis reveals that one memberof the chromosome 1 pair (in group A) contains an inversioncovering 70 percent of its length. The homolog of chromosome1 and all other chromosomes show the normal bandingsequence. Question: How would you explain the high incidence of paststillbirths?
Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
A couple planning their family are aware that through the past
three generations on the husband’s side a substantial number
of stillbirths have occurred and several malformed babies were
born who died early in childhood. The wife has studied genetics
and urges her husband to visit a genetic counseling clinic,
where a complete karyotype-banding analysis is performed.
Although the tests show that he has a normal complement of
46 chromosomes, banding analysis reveals that one member
of the chromosome 1 pair (in group A) contains an inversion
covering 70 percent of its length. The homolog of chromosome
1 and all other chromosomes show the normal banding
sequence.
Question: How would you explain the high incidence of past
stillbirths?
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