How to draw titration of amino acids ?what happen when ph increase from low to high? 1. what does it means when pka and ph are equal? 2. Did I calculate p1 correctly?? 3. Does cysteine lose H in SH ?should it be positively charged or negatively charged after lose H and why??

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter25: Nitrogen Acquisition And Amino Acid Metabolism
Section: Chapter Questions
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How to draw titration of amino acids ?what happen when ph increase from low to high? 1. what does it means when pka and ph are equal? 2. Did I calculate p1 correctly?? 3. Does cysteine lose H in SH ?should it be positively charged or negatively charged after lose H and why??
Histidine.
аон
H₂N²-C - H
CH₂
|| M
\N//
+ H
Co
Coo
+1
H ~ H³N² C-H = H₂N-C-H ~ H₂N-C-H
PK9=PH=1.82 CH² Pha=PH=6.0 CH² PRAZPH=9.17 07/1₂
en
IMH
M
\N/
+H
(1+)
(2+)
cysteine
cos
аон
1
NH÷-C-H ~ M÷-C-H
GCH2
1
SH
(+1)
P₁ =
CH2
हम
(0)
Pra-PH=1-711
P₁ =
\N/
+H
(0)
6.0+ 9.7
2
2
1.71+8.33
كيف
CH₂
SH
(-1)
= 15.17
2
N/
(-1)
=NH₂=C-H = H₂C-H
CH₂
Pha-PH=8.331 Pha=PH= 10.78
7.585,
S
e
er
n
t
Transcribed Image Text:Histidine. аон H₂N²-C - H CH₂ || M \N// + H Co Coo +1 H ~ H³N² C-H = H₂N-C-H ~ H₂N-C-H PK9=PH=1.82 CH² Pha=PH=6.0 CH² PRAZPH=9.17 07/1₂ en IMH M \N/ +H (1+) (2+) cysteine cos аон 1 NH÷-C-H ~ M÷-C-H GCH2 1 SH (+1) P₁ = CH2 हम (0) Pra-PH=1-711 P₁ = \N/ +H (0) 6.0+ 9.7 2 2 1.71+8.33 كيف CH₂ SH (-1) = 15.17 2 N/ (-1) =NH₂=C-H = H₂C-H CH₂ Pha-PH=8.331 Pha=PH= 10.78 7.585, S e er n t
Expert Solution
Amino acids can act like an weak acid or base

Amino acids are biomolecules that have an amino group and a carboxyl group linked to the same carbon called alpha carbon. Other than the amino and carboxyl groups, amino acids have a side chain linked to the alpha carbon. Amino acids differ from each other in the side group that is linked to the alpha carbon. 

The alpha-amino group and alpha-carboxyl groups are ionisable, the side group is ionisable in only some amino acids. When amino acids are dissolved in water, they can act either like an acid or like a base. This is why they are called dipolar ions or zwitterion.  

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