How to draw titration of amino acids ?what happen when ph increase from low to high? 1. what does it means when pka and ph are equal? 2. Did I calculate p1 correctly?? 3. Does cysteine lose H in SH ?should it be positively charged or negatively charged after lose H and why??
How to draw titration of amino acids ?what happen when ph increase from low to high? 1. what does it means when pka and ph are equal? 2. Did I calculate p1 correctly?? 3. Does cysteine lose H in SH ?should it be positively charged or negatively charged after lose H and why??
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter25: Nitrogen Acquisition And Amino Acid Metabolism
Section: Chapter Questions
Problem 9P
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How to draw titration of amino acids ?what happen when ph increase from low to high?
1. what does it means when pka and ph are equal?
2. Did I calculate p1 correctly??
3. Does cysteine lose H in SH ?should it be positively charged or negatively charged after lose H and why??

Transcribed Image Text:Histidine.
аон
H₂N²-C - H
CH₂
|| M
\N//
+ H
Co
Coo
+1
H ~ H³N² C-H = H₂N-C-H ~ H₂N-C-H
PK9=PH=1.82 CH² Pha=PH=6.0 CH² PRAZPH=9.17 07/1₂
en
IMH
M
\N/
+H
(1+)
(2+)
cysteine
cos
аон
1
NH÷-C-H ~ M÷-C-H
GCH2
1
SH
(+1)
P₁ =
CH2
हम
(0)
Pra-PH=1-711
P₁ =
\N/
+H
(0)
6.0+ 9.7
2
2
1.71+8.33
كيف
CH₂
SH
(-1)
= 15.17
2
N/
(-1)
=NH₂=C-H = H₂C-H
CH₂
Pha-PH=8.331 Pha=PH= 10.78
7.585,
S
e
er
n
t
Expert Solution

Amino acids can act like an weak acid or base
Amino acids are biomolecules that have an amino group and a carboxyl group linked to the same carbon called alpha carbon. Other than the amino and carboxyl groups, amino acids have a side chain linked to the alpha carbon. Amino acids differ from each other in the side group that is linked to the alpha carbon.
The alpha-amino group and alpha-carboxyl groups are ionisable, the side group is ionisable in only some amino acids. When amino acids are dissolved in water, they can act either like an acid or like a base. This is why they are called dipolar ions or zwitterion.
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