Friedewald equation is an indirect method, used to estimate LDL from the measurement of total cholesterol. What are two main limitations of using this equation? Suggest another method as an alternative to the Friedewald calculation. List two advantages of the method that you have suggested in 2b (v).

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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b) Low-Density Lipoprotein (LDL) is the major carrier of cholesterol in the blood. Whereas
the levels of LDL and modified LDL forms in the plasma are important predictive
markers to gauge the risk of cardiovascular events. There is a need to develop reliable
rapid assays for quantifying LDL and its modified forms, such as, the biosensors.
iv.
Friedewald equation is an indirect method, used to estimate LDL from the
measurement of total cholesterol. What are two main limitations of using this
equation?
Suggest another method as an alternative to the Friedewald calculation.
V.
vi.
List two advantages of the method that you have suggested in 2b (v).
Transcribed Image Text:b) Low-Density Lipoprotein (LDL) is the major carrier of cholesterol in the blood. Whereas the levels of LDL and modified LDL forms in the plasma are important predictive markers to gauge the risk of cardiovascular events. There is a need to develop reliable rapid assays for quantifying LDL and its modified forms, such as, the biosensors. iv. Friedewald equation is an indirect method, used to estimate LDL from the measurement of total cholesterol. What are two main limitations of using this equation? Suggest another method as an alternative to the Friedewald calculation. V. vi. List two advantages of the method that you have suggested in 2b (v).
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