explain why A liposome of 1;1 molar ratio of cholesterol to phospholipids will be the optimum combination for the highest concentration of drug entrapment’
Q: does an increase in cholesterol concentration increase encapsulation efficiency of a drug
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explain why A liposome of 1;1 molar ratio of cholesterol to phospholipids will be the optimum combination for the highest concentration of drug entrapment’
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- what possible outcome may be produced when the molecular weight of an alcohol antiseptic is increase to a C20, will it still be effective? Explain your answerFrom a medicinal chemistry (and a pharmacologist) perspective, functional groups provide specific properties and behaviors that allow drug molecules to exert their desired PD and PK effects. The key point here is that each individual group within a drug molecule can serve to provide one or more specific roles, tasks, or functions. The following table summarizes a series of drug discovery lead optimization for targeting a certain renal disease. Explain the basis for changing the R- functionality at the para- position. Please explain in as much detail as you need and by using scientific justifications, which one of the 4 candidates (526-529), presents the most viable investigational drug candidate, given the information provided below? N- `N' 'N' R- Drug Code R IC30 (nM) Half-Life (tı2), Minutes 526 CH;O 104 6 527 CF;0 1110 95 528 CH;CH, 11 <5 529 CH,CF, 14 96Polyethylene glycol (PEG)-conjugated IFNs have superior pharmaceutical properties compared with their unconjugated counterparts as a result of greater protection against proteolytic degradation, better solubility, and slower catabolism and excretion. Group of answer choices True False
- Which option is true about Chymotrypsin mechanism of action? Must select all true options. No part marks. A) General acid catalysis followed by general base catalysis in the 2nd transition state B) General acid catalysis followed by general base catalysis in the 1st transition state C) General base catalysis followed by general acid catalysis 1st transition state D) General base catalysis followed by general acid catalysis in the 2nd transition stateCimetidine is used in the treatment and management of gastric ulcers and gastroesophageal reflux disease. In the case of an active ulcer, cimetidine can be administered continuous by IV infusion at a dose rate of 37.5 mg/hr. If the concentration of the cimetidine solution is 6 mg/ml, then how many milliliters must be available for a 4-hr infusion?Misoprostol is used to prevent NSAID-induced gastric ulcers. A daily dose consists of two tablets administered four times each day. What is the size of one day’s dose if each tablet contains 100 mcg of misoprostol?I need hand written solution only
- For a weak ester drug that is unstable in highly acidic or alkaline solutions, what strategies could be used to make this drug more bioavailable after oral administration?A decapeptide was isolated from a thermophilic bacteria. Treatment of this peptide with 2- mercaptoethanol gave 2 pentapeptides. Further analysis of this peptide gave the following data: Trypsin: (M,Y), (K,Y,M), (K, 2A, 2C) Chymotrypsin: (2K, 2A, 2C, Y), (M), (Y,M) What is the primary structure of the decapeptide? Thank you.Explain the Titrimetric profile of Lysine in figure 2.
- Considering the general structure of penicillins, how are they rendered ineffective? Select one: a. β-Lactamase performs nucleophilic attack of the amide in the penicillin side chain b. β-Lactamase performs nucleophilic attack of the amide in the β-lactam ring and subsequently hydrolyzes this intermediate c. β-Lactamase performs nucleophilic attack of the thiazolidone ring on the carbon next to the electronegative sulfur leading to a covalently inhibited β-Lactamase d. All of these e. None of theseThe plasma profiles of codeine (COD) and metabolites for 2 individuals (labeled A and B) are shown below. The X-axis is time in hours after an oral dose of codeine. [M=morphine; C6G=COD-6-glucuronide; M3G = morphine-3-glucuronide; NM (ignore)]. Note the data is shown on a log scale on the Y-axis. (A) Which individual is the poor metabolizer? Explain how you know this from the profiles? (B) Is this a problem for cough suppression? Explain. -CH HO Codeine COD 10 000 1000 C6G COD 100 M3G M6G NM 10 M 10 20 30 0 10 20 30 Plasma concentration (nmol I-)Describe in detail synthesis route (home-cooking recipe) of methamphetamine from pseudoephedrine. What supplies and ingredients are needed and where could one get these ingredients from? How easy would it be to synthesize methamphetamine in a home-made laboratory. Provide sources as well.