Protease enzymes cleave proteins by hydrolyzing peptide bonds. The strategy for each type of metalloprotease begins with generating a nucleophile that attacks the peptide bond that attacks the peptide carbonyl group. On the basis of the information provided in the figure, show the next step in the mechanism for peptide-bond cleavage by a Cysteine protease. H Cysteine proteases N R2 HN R1

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