Experimental measurements of the reversible interaction between a drug and its receptor show k.=0.005 min and K, = 16 pM. a) Write the reaction scheme. b) Calculate the binding half-lives in solutions with drug concentrations of 1, 10, 100, and 1000 pM. c) Plot the half-life vs drug concentration, and explain how drug concentration affects binding kinetics at very low and very high concentrations.

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Clinical Pharmacology

Pharmacology is a discipline of medicine that studies how medications interact with the systems and processes of living organisms, focusing on drug action mechanisms as well as therapeutic and other purposes.