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CHM3413-Neutral vs lonized consider the table of drugs shown below and their respective pka value(s). Complete the table by drawing the relevant portion of the drug molecule in its IONIZED form. Indicate whether the ion is the conjugate acid or conjugate base of the neutral drug, if two pka values are listed, then two ionized structures must be drawn. Drug Name Neutral Form (Neutral) pka from table Baclofen Captopril Ampicillin НА ВН+ 5.4 9.5 3.7 9.8 2.5 7.2 Doxycycline 3.4 95 2. 7.7 H H₂C HS yo NH₂ O OH OH NH S CH₂ fot OH ON lonized Form(s) Is/are the ION(s) a conj. acid or conj, base? CA or CB? % ionized at physiological pH?

CHM3413-Neutral vs lonized consider the table of drugs shown below and their respective pka value(s). Complete the table by drawing the relevant portion of the drug molecule in its IONIZED form. Indicate whether the ion is the conjugate acid or conjugate base of the neutral drug, if two pka values are listed, then two ionized structures must be drawn. Drug Name Neutral Form (Neutral) pka from table Baclofen Captopril Ampicillin НА ВН+ 5.4 9.5 3.7 9.8 2.5 7.2 Doxycycline 3.4 95 2. 7.7 H H₂C HS yo NH₂ O OH OH NH S CH₂ fot OH ON lonized Form(s) Is/are the ION(s) a conj. acid or conj, base? CA or CB? % ionized at physiological pH?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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CHM3413-Neutral vs lonized... consider the table of drugs shown below and their respective pka value(s). Complete the table by drawing the relevant portion of the drug molecule in its IONIZED form. Indicate whether the ion is the conjugate acid or conjugate base of the neutral drug, if two pka values are listed, then two ionized structures must be drawn. Drug Name: Neutral Form (Neutral) pka from table HA BH+ 5.4 9.5 Baclofen Captopril Ampicillin 3.7 M 9.8 2.5 7.2 Doxycycline 3.4 9.5 7.7 H H₂C HS 1,0 NH₂ Pho OH OH NH H OH S CH₂ NCH₂ OH 0 150 ONN-C H OH 0 CON 6 M lonized Form(s) Is/are the ION(s) a conj. acid or conj, base? CA or CB? % ionized at physiological pH?
Transcribed Image Text:CHM3413-Neutral vs lonized... consider the table of drugs shown below and their respective pka value(s). Complete the table by drawing the relevant portion of the drug molecule in its IONIZED form. Indicate whether the ion is the conjugate acid or conjugate base of the neutral drug, if two pka values are listed, then two ionized structures must be drawn. Drug Name: Neutral Form (Neutral) pka from table HA BH+ 5.4 9.5 Baclofen Captopril Ampicillin 3.7 M 9.8 2.5 7.2 Doxycycline 3.4 9.5 7.7 H H₂C HS 1,0 NH₂ Pho OH OH NH H OH S CH₂ NCH₂ OH 0 150 ONN-C H OH 0 CON 6 M lonized Form(s) Is/are the ION(s) a conj. acid or conj, base? CA or CB? % ionized at physiological pH?
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