During template-directed synthesis of a new DNA strand it can happen, if there are simple repeated sequences, that either the template strand or the strand being synthesized "slips" a short distance, and this can change the number of repeating sequence units in that stretch of repeated sequence. Which of the following processes involve such slippage? More than one answer is correct. Options: The increase in genomic copy number of a DNA transposon by transposition from a location behind a replication fork to a location ahead of the fork. Introduction of indels during DNA replication. The initial unwinding of the DNA duplex during replication by helicase. Increasing lengths of CAG trinucleotide repeats in the huntingtin gene giving rise to Huntington disease. Synthesis of primer by primase during DNA replication.
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
During template-directed synthesis of a new DNA strand it can happen, if there are simple repeated sequences, that either the template strand or the strand being synthesized "slips" a short distance, and this can change the number of repeating sequence units in that stretch of repeated sequence. Which of the following processes involve such slippage?
More than one answer is correct.
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The increase in genomic copy number of a DNA transposon by transposition from a location behind a replication fork to a location ahead of the fork. |
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Introduction of indels during |
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The initial unwinding of the DNA duplex during replication by helicase. |
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|
Increasing lengths of CAG trinucleotide repeats in the huntingtin gene giving rise to Huntington disease. |
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Synthesis of primer by primase during DNA replication. |
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